Cu-Catalyzed Arylation of Bromo-Difluoro-Acetamides by Aryl Boronic Acids, Aryl Trialkoxysilanes and Dimethyl-Aryl-Sulfonium Salts: New Entries to Aromatic Amides

We describe a mechanism-guided discovery of a synthetic methodology that enables the preparation of aromatic amides from 2-bromo-2,2-difluoroacetamides utilizing a copper-catalyzed direct arylation. Readily available and structurally simple aryl precursors such as aryl boronic acids, aryl trialkoxys...

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Detalles Bibliográficos
Autores principales: Mkrtchyan, Satenik, Jakubczyk, Michał, Lanka, Suneel, Pittelkow, Michael, Iaroshenko, Viktor O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156957/
https://www.ncbi.nlm.nih.gov/pubmed/34065691
http://dx.doi.org/10.3390/molecules26102957

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156957/
https://www.ncbi.nlm.nih.gov/pubmed/34065691
http://dx.doi.org/10.3390/molecules26102957

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