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Evaluating Mechanisms of IDH1 Regulation through Site-Specific Acetylation Mimics

Isocitrate dehydrogenase (IDH1) catalyzes the reversible NADP(+)-dependent oxidation of isocitrate to α-ketoglutarate (αKG). IDH1 mutations, primarily R132H, drive > 80% of low-grade gliomas and secondary glioblastomas and facilitate the NADPH-dependent reduction of αKG to the oncometabolite D-2-...

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Detalles Bibliográficos
Autores principales:	Weeks, Joi, Strom, Alexandra I., Widjaja, Vinnie, Alexander, Sati, Pucher, Dahra K., Sohl, Christal D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157008/ https://www.ncbi.nlm.nih.gov/pubmed/34065652 http://dx.doi.org/10.3390/biom11050740

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