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Analysis of Cannabinoids Concentration in Cannabis Oil Galenic Preparations: Harmonization between Three Laboratories in Northern Italy
Medical cannabis is increasingly being used in the treatment and support of several diseases and syndromes. The quantitative determination of active ingredients (delta-9 tetrahydrocannabinol, THC, and cannabidiol, CBD) in galenic oily preparations is prescribed by law for each produced batch. The ai...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157009/ https://www.ncbi.nlm.nih.gov/pubmed/34069020 http://dx.doi.org/10.3390/ph14050462 |
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author | Palermiti, Alice Cafaro, Alessia Barco, Sebastiano Bucchioni, Paolo Franceschini, Paolo Cusato, Jessica De Nicolò, Amedeo Manca, Alessandra De Vivo, Elisa Delia Russo, Eleonora Cecchi, Francesco Pigliasco, Federica Lillo, Flavia Tripodi, Gino D’Avolio, Antonio Cangemi, Giuliana |
author_facet | Palermiti, Alice Cafaro, Alessia Barco, Sebastiano Bucchioni, Paolo Franceschini, Paolo Cusato, Jessica De Nicolò, Amedeo Manca, Alessandra De Vivo, Elisa Delia Russo, Eleonora Cecchi, Francesco Pigliasco, Federica Lillo, Flavia Tripodi, Gino D’Avolio, Antonio Cangemi, Giuliana |
author_sort | Palermiti, Alice |
collection | PubMed |
description | Medical cannabis is increasingly being used in the treatment and support of several diseases and syndromes. The quantitative determination of active ingredients (delta-9 tetrahydrocannabinol, THC, and cannabidiol, CBD) in galenic oily preparations is prescribed by law for each produced batch. The aim of this work is to describe the organization of the titration activity centralized at three regional reference laboratories in Northern Italy. Pre-analytical, analytical, and post-analytical phases have been defined in order to guarantee high quality standards. A cross-validation between laboratories allowed for the definition of the procedures that guarantee the interchangeability between reference laboratories. The risk management protocol adopted can be useful for others who need to undertake this activity. |
format | Online Article Text |
id | pubmed-8157009 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81570092021-05-28 Analysis of Cannabinoids Concentration in Cannabis Oil Galenic Preparations: Harmonization between Three Laboratories in Northern Italy Palermiti, Alice Cafaro, Alessia Barco, Sebastiano Bucchioni, Paolo Franceschini, Paolo Cusato, Jessica De Nicolò, Amedeo Manca, Alessandra De Vivo, Elisa Delia Russo, Eleonora Cecchi, Francesco Pigliasco, Federica Lillo, Flavia Tripodi, Gino D’Avolio, Antonio Cangemi, Giuliana Pharmaceuticals (Basel) Article Medical cannabis is increasingly being used in the treatment and support of several diseases and syndromes. The quantitative determination of active ingredients (delta-9 tetrahydrocannabinol, THC, and cannabidiol, CBD) in galenic oily preparations is prescribed by law for each produced batch. The aim of this work is to describe the organization of the titration activity centralized at three regional reference laboratories in Northern Italy. Pre-analytical, analytical, and post-analytical phases have been defined in order to guarantee high quality standards. A cross-validation between laboratories allowed for the definition of the procedures that guarantee the interchangeability between reference laboratories. The risk management protocol adopted can be useful for others who need to undertake this activity. MDPI 2021-05-14 /pmc/articles/PMC8157009/ /pubmed/34069020 http://dx.doi.org/10.3390/ph14050462 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Palermiti, Alice Cafaro, Alessia Barco, Sebastiano Bucchioni, Paolo Franceschini, Paolo Cusato, Jessica De Nicolò, Amedeo Manca, Alessandra De Vivo, Elisa Delia Russo, Eleonora Cecchi, Francesco Pigliasco, Federica Lillo, Flavia Tripodi, Gino D’Avolio, Antonio Cangemi, Giuliana Analysis of Cannabinoids Concentration in Cannabis Oil Galenic Preparations: Harmonization between Three Laboratories in Northern Italy |
title | Analysis of Cannabinoids Concentration in Cannabis Oil Galenic Preparations: Harmonization between Three Laboratories in Northern Italy |
title_full | Analysis of Cannabinoids Concentration in Cannabis Oil Galenic Preparations: Harmonization between Three Laboratories in Northern Italy |
title_fullStr | Analysis of Cannabinoids Concentration in Cannabis Oil Galenic Preparations: Harmonization between Three Laboratories in Northern Italy |
title_full_unstemmed | Analysis of Cannabinoids Concentration in Cannabis Oil Galenic Preparations: Harmonization between Three Laboratories in Northern Italy |
title_short | Analysis of Cannabinoids Concentration in Cannabis Oil Galenic Preparations: Harmonization between Three Laboratories in Northern Italy |
title_sort | analysis of cannabinoids concentration in cannabis oil galenic preparations: harmonization between three laboratories in northern italy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157009/ https://www.ncbi.nlm.nih.gov/pubmed/34069020 http://dx.doi.org/10.3390/ph14050462 |
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