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Living-Cell Diffracted X-ray Tracking Analysis Confirmed Internal Salt Bridge Is Critical for Ligand-Induced Twisting Motion of Serotonin Receptors

Serotonin receptors play important roles in neuronal excitation, emotion, platelet aggregation, and vasoconstriction. The serotonin receptor subtype 2A (5-HT(2A)R) is a Gq-coupled GPCR, which activate phospholipase C. Although the structures and functions of 5-HT(2A)Rs have been well studied, little...

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Detalles Bibliográficos
Autores principales:	Mio, Kazuhiro, Fujimura, Shoko, Ishihara, Masaki, Kuramochi, Masahiro, Sekiguchi, Hiroshi, Kubo, Tai, Sasaki, Yuji C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157010/ https://www.ncbi.nlm.nih.gov/pubmed/34067933 http://dx.doi.org/10.3390/ijms22105285

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