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Antibacterial Porous Coaxial Drug-Carrying Nanofibers for Sustained Drug-Releasing Applications

The phenomenon of drug burst release is the main problem in the field of drug delivery systems, as it means that a good therapeutic effect cannot be acheived. Nanofibers developed by electrospinning technology have large specific surface areas, high porosity, and easily controlled morphology. They a...

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Autores principales: Chen, Xin, Li, Honghai, Lu, Weipeng, Guo, Yanchuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157037/
https://www.ncbi.nlm.nih.gov/pubmed/34067723
http://dx.doi.org/10.3390/nano11051316
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author Chen, Xin
Li, Honghai
Lu, Weipeng
Guo, Yanchuan
author_facet Chen, Xin
Li, Honghai
Lu, Weipeng
Guo, Yanchuan
author_sort Chen, Xin
collection PubMed
description The phenomenon of drug burst release is the main problem in the field of drug delivery systems, as it means that a good therapeutic effect cannot be acheived. Nanofibers developed by electrospinning technology have large specific surface areas, high porosity, and easily controlled morphology. They are being considered as potential carriers for sustained drug release. In this paper, we obtained polycaprolactone (PCL)/polylactic acid (PLA) core-shell porous drug-carrying nanofibers by using coaxial electrospinning technology and the nonsolvent-induced phase separation method. Roxithromycin (ROX), a kind of antibacterial agent, was encapsulated in the core layer. The morphology, composition, and thermal properties of the resultant nanofibers were characterized by scanning electron microscopy (SEM), attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, differential scanning calorimetry (DSC) and thermogravimetry analysis (TGA). Besides this, the in vitro drug release profile was investigated; it showed that the release rate of the prepared coaxial porous nanofibers with two different pore sizes was 30.10 ± 3.51% and 35.04 ± 1.98% in the first 30 min, and became 92.66 ± 3.13% and 88.94 ± 1.58% after 14 days. Compared with the coaxial nonporous nanofibers and nanofibers prepared by uniaxial electrospinning with or without pores, the prepared coaxial porous nanofibers revealed that the burst release was mitigated and the dissolution rate of the hydrophobic drugs was increased. The further antimicrobial activity demonstrated that the inhibition zone diameter of the coaxial nanofibers with two different pore sizes was 1.70 ± 0.10 cm and 1.73 ± 0.23 cm, exhibiting a good antibacterial effect against Staphylococcus aureus. Therefore, the prepared nanofibers with the coaxial porous structures could serve as promising drug delivery systems.
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spelling pubmed-81570372021-05-28 Antibacterial Porous Coaxial Drug-Carrying Nanofibers for Sustained Drug-Releasing Applications Chen, Xin Li, Honghai Lu, Weipeng Guo, Yanchuan Nanomaterials (Basel) Article The phenomenon of drug burst release is the main problem in the field of drug delivery systems, as it means that a good therapeutic effect cannot be acheived. Nanofibers developed by electrospinning technology have large specific surface areas, high porosity, and easily controlled morphology. They are being considered as potential carriers for sustained drug release. In this paper, we obtained polycaprolactone (PCL)/polylactic acid (PLA) core-shell porous drug-carrying nanofibers by using coaxial electrospinning technology and the nonsolvent-induced phase separation method. Roxithromycin (ROX), a kind of antibacterial agent, was encapsulated in the core layer. The morphology, composition, and thermal properties of the resultant nanofibers were characterized by scanning electron microscopy (SEM), attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, differential scanning calorimetry (DSC) and thermogravimetry analysis (TGA). Besides this, the in vitro drug release profile was investigated; it showed that the release rate of the prepared coaxial porous nanofibers with two different pore sizes was 30.10 ± 3.51% and 35.04 ± 1.98% in the first 30 min, and became 92.66 ± 3.13% and 88.94 ± 1.58% after 14 days. Compared with the coaxial nonporous nanofibers and nanofibers prepared by uniaxial electrospinning with or without pores, the prepared coaxial porous nanofibers revealed that the burst release was mitigated and the dissolution rate of the hydrophobic drugs was increased. The further antimicrobial activity demonstrated that the inhibition zone diameter of the coaxial nanofibers with two different pore sizes was 1.70 ± 0.10 cm and 1.73 ± 0.23 cm, exhibiting a good antibacterial effect against Staphylococcus aureus. Therefore, the prepared nanofibers with the coaxial porous structures could serve as promising drug delivery systems. MDPI 2021-05-17 /pmc/articles/PMC8157037/ /pubmed/34067723 http://dx.doi.org/10.3390/nano11051316 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Xin
Li, Honghai
Lu, Weipeng
Guo, Yanchuan
Antibacterial Porous Coaxial Drug-Carrying Nanofibers for Sustained Drug-Releasing Applications
title Antibacterial Porous Coaxial Drug-Carrying Nanofibers for Sustained Drug-Releasing Applications
title_full Antibacterial Porous Coaxial Drug-Carrying Nanofibers for Sustained Drug-Releasing Applications
title_fullStr Antibacterial Porous Coaxial Drug-Carrying Nanofibers for Sustained Drug-Releasing Applications
title_full_unstemmed Antibacterial Porous Coaxial Drug-Carrying Nanofibers for Sustained Drug-Releasing Applications
title_short Antibacterial Porous Coaxial Drug-Carrying Nanofibers for Sustained Drug-Releasing Applications
title_sort antibacterial porous coaxial drug-carrying nanofibers for sustained drug-releasing applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157037/
https://www.ncbi.nlm.nih.gov/pubmed/34067723
http://dx.doi.org/10.3390/nano11051316
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AT lihonghai antibacterialporouscoaxialdrugcarryingnanofibersforsustaineddrugreleasingapplications
AT luweipeng antibacterialporouscoaxialdrugcarryingnanofibersforsustaineddrugreleasingapplications
AT guoyanchuan antibacterialporouscoaxialdrugcarryingnanofibersforsustaineddrugreleasingapplications