Oral Administration of Ginger-Derived Lipid Nanoparticles and Dmt1 siRNA Potentiates the Effect of Dietary Iron Restriction and Mitigates Pre-Existing Iron Overload in Hamp KO Mice

Intestinal iron transport requires an iron importer (Dmt1) and an iron exporter (Fpn1). The hormone hepcidin regulates iron absorption by modulating Fpn1 protein levels on the basolateral surface of duodenal enterocytes. In the genetic, iron-loading disorder hereditary hemochromatosis (HH), hepcidin...

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Detalles Bibliográficos
Autores principales: Wang, Xiaoyu, Zhang, Mingzhen, Woloshun, Regina R., Yu, Yang, Lee, Jennifer K., Flores, Shireen R. L., Merlin, Didier, Collins, James F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157040/
https://www.ncbi.nlm.nih.gov/pubmed/34063414
http://dx.doi.org/10.3390/nu13051686

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