Cargando…

High Prevalence of Epilepsy in an Onchocerciasis-Endemic Area in Mvolo County, South Sudan: A Door-To-Door Survey

In June 2020, a door-to-door household survey was conducted in Mvolo County, an onchocerciasis-endemic area in South Sudan. A total of 2357 households containing 15,699 individuals agreed to participate in the study. Of these, 5046 (32.1%, 95% CI: 31.4–32.9%) had skin itching and 445 (2.8%, 95% CI:...

Descripción completa

Detalles Bibliográficos
Autores principales: Raimon, Stephen, Dusabimana, Alfred, Abd-Elfarag, Gasim, Okaro, Samuel, Carter, Jane Y., Newton, Charles R., Logora, Makoy Yibi, Colebunders, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157079/
https://www.ncbi.nlm.nih.gov/pubmed/34068976
http://dx.doi.org/10.3390/pathogens10050599
_version_ 1783699599960047616
author Raimon, Stephen
Dusabimana, Alfred
Abd-Elfarag, Gasim
Okaro, Samuel
Carter, Jane Y.
Newton, Charles R.
Logora, Makoy Yibi
Colebunders, Robert
author_facet Raimon, Stephen
Dusabimana, Alfred
Abd-Elfarag, Gasim
Okaro, Samuel
Carter, Jane Y.
Newton, Charles R.
Logora, Makoy Yibi
Colebunders, Robert
author_sort Raimon, Stephen
collection PubMed
description In June 2020, a door-to-door household survey was conducted in Mvolo County, an onchocerciasis-endemic area in South Sudan. A total of 2357 households containing 15,699 individuals agreed to participate in the study. Of these, 5046 (32.1%, 95% CI: 31.4–32.9%) had skin itching and 445 (2.8%, 95% CI: 2.6–3.1%) were blind. An epilepsy screening questionnaire identified 813 (5.1%) persons suspected of having epilepsy. Of them, 804 (98.9%) were seen by a medical doctor, and in 798 (98.1%) the diagnosis of epilepsy was confirmed. The overall epilepsy prevalence was 50.8/1000 (95% CI: 47.6–54.4/1000), while the prevalence of nodding syndrome was 22.4/1000 (95% CI: 20.1–24.9/1000). Younger age, being male, skin itching, blindness, and living in a neighbourhood or village close to the Naam River were risk factors for epilepsy. The annual incidence of epilepsy was 82.8/100,000 (95% CI: 44.1–141.6/100,000). Among children 7–9 years old without epilepsy, 34% were Ov16 seropositive, suggesting high ongoing Onchocerca volvulus transmission, but only 41.9% of them took ivermectin during the last mass distribution. In conclusion, a high prevalence and incidence of epilepsy was observed in Mvolo, South Sudan. Strengthening of the onchocerciasis elimination programme is urgently needed in order to prevent epilepsy in this region.
format Online
Article
Text
id pubmed-8157079
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-81570792021-05-28 High Prevalence of Epilepsy in an Onchocerciasis-Endemic Area in Mvolo County, South Sudan: A Door-To-Door Survey Raimon, Stephen Dusabimana, Alfred Abd-Elfarag, Gasim Okaro, Samuel Carter, Jane Y. Newton, Charles R. Logora, Makoy Yibi Colebunders, Robert Pathogens Article In June 2020, a door-to-door household survey was conducted in Mvolo County, an onchocerciasis-endemic area in South Sudan. A total of 2357 households containing 15,699 individuals agreed to participate in the study. Of these, 5046 (32.1%, 95% CI: 31.4–32.9%) had skin itching and 445 (2.8%, 95% CI: 2.6–3.1%) were blind. An epilepsy screening questionnaire identified 813 (5.1%) persons suspected of having epilepsy. Of them, 804 (98.9%) were seen by a medical doctor, and in 798 (98.1%) the diagnosis of epilepsy was confirmed. The overall epilepsy prevalence was 50.8/1000 (95% CI: 47.6–54.4/1000), while the prevalence of nodding syndrome was 22.4/1000 (95% CI: 20.1–24.9/1000). Younger age, being male, skin itching, blindness, and living in a neighbourhood or village close to the Naam River were risk factors for epilepsy. The annual incidence of epilepsy was 82.8/100,000 (95% CI: 44.1–141.6/100,000). Among children 7–9 years old without epilepsy, 34% were Ov16 seropositive, suggesting high ongoing Onchocerca volvulus transmission, but only 41.9% of them took ivermectin during the last mass distribution. In conclusion, a high prevalence and incidence of epilepsy was observed in Mvolo, South Sudan. Strengthening of the onchocerciasis elimination programme is urgently needed in order to prevent epilepsy in this region. MDPI 2021-05-14 /pmc/articles/PMC8157079/ /pubmed/34068976 http://dx.doi.org/10.3390/pathogens10050599 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Raimon, Stephen
Dusabimana, Alfred
Abd-Elfarag, Gasim
Okaro, Samuel
Carter, Jane Y.
Newton, Charles R.
Logora, Makoy Yibi
Colebunders, Robert
High Prevalence of Epilepsy in an Onchocerciasis-Endemic Area in Mvolo County, South Sudan: A Door-To-Door Survey
title High Prevalence of Epilepsy in an Onchocerciasis-Endemic Area in Mvolo County, South Sudan: A Door-To-Door Survey
title_full High Prevalence of Epilepsy in an Onchocerciasis-Endemic Area in Mvolo County, South Sudan: A Door-To-Door Survey
title_fullStr High Prevalence of Epilepsy in an Onchocerciasis-Endemic Area in Mvolo County, South Sudan: A Door-To-Door Survey
title_full_unstemmed High Prevalence of Epilepsy in an Onchocerciasis-Endemic Area in Mvolo County, South Sudan: A Door-To-Door Survey
title_short High Prevalence of Epilepsy in an Onchocerciasis-Endemic Area in Mvolo County, South Sudan: A Door-To-Door Survey
title_sort high prevalence of epilepsy in an onchocerciasis-endemic area in mvolo county, south sudan: a door-to-door survey
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157079/
https://www.ncbi.nlm.nih.gov/pubmed/34068976
http://dx.doi.org/10.3390/pathogens10050599
work_keys_str_mv AT raimonstephen highprevalenceofepilepsyinanonchocerciasisendemicareainmvolocountysouthsudanadoortodoorsurvey
AT dusabimanaalfred highprevalenceofepilepsyinanonchocerciasisendemicareainmvolocountysouthsudanadoortodoorsurvey
AT abdelfaraggasim highprevalenceofepilepsyinanonchocerciasisendemicareainmvolocountysouthsudanadoortodoorsurvey
AT okarosamuel highprevalenceofepilepsyinanonchocerciasisendemicareainmvolocountysouthsudanadoortodoorsurvey
AT carterjaney highprevalenceofepilepsyinanonchocerciasisendemicareainmvolocountysouthsudanadoortodoorsurvey
AT newtoncharlesr highprevalenceofepilepsyinanonchocerciasisendemicareainmvolocountysouthsudanadoortodoorsurvey
AT logoramakoyyibi highprevalenceofepilepsyinanonchocerciasisendemicareainmvolocountysouthsudanadoortodoorsurvey
AT colebundersrobert highprevalenceofepilepsyinanonchocerciasisendemicareainmvolocountysouthsudanadoortodoorsurvey