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Computational Treatment Simulations to Assess the Need for Personalized Tamoxifen Dosing in Breast Cancer Patients of Different Biogeographical Groups

SIMPLE SUMMARY: Tamoxifen is a drug often used to treat the most common type of breast cancer. Its metabolite endoxifen is formed by the liver enzyme CYP2D6, whose activity is variable and depends on a patient’s genetic profile. The frequency of CYP2D6 variants with different functional enzymatic ac...

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Detalles Bibliográficos
Autores principales:	Mueller-Schoell, Anna, Michelet, Robin, Klopp-Schulze, Lena, van Dyk, Madelé, Mürdter, Thomas E., Schwab, Matthias, Joerger, Markus, Huisinga, Wilhelm, Mikus, Gerd, Kloft, Charlotte
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157244/ https://www.ncbi.nlm.nih.gov/pubmed/34069810 http://dx.doi.org/10.3390/cancers13102432

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