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Analysis of Frailty in Geriatric Patients as a Prognostic Factor in Endovascular Treated Patients with Large Vessel Occlusion Strokes

Frailty is associated with an increased risk of adverse health-care outcomes in elderly patients. The Hospital Frailty Risk Score (HFRS) has been developed and proven to be capable of identifying patients which are at high risk of adverse outcomes. We aimed to investigate whether frail patients also...

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Autores principales: Schnieder, Marlena, Bähr, Mathias, Kirsch, Mareike, Maier, Ilko, Behme, Daniel, Riedel, Christian Heiner, Psychogios, Marios-Nikos, Brehm, Alex, Liman, Jan, von Arnim, Christine A. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157268/
https://www.ncbi.nlm.nih.gov/pubmed/34069797
http://dx.doi.org/10.3390/jcm10102171
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author Schnieder, Marlena
Bähr, Mathias
Kirsch, Mareike
Maier, Ilko
Behme, Daniel
Riedel, Christian Heiner
Psychogios, Marios-Nikos
Brehm, Alex
Liman, Jan
von Arnim, Christine A. F.
author_facet Schnieder, Marlena
Bähr, Mathias
Kirsch, Mareike
Maier, Ilko
Behme, Daniel
Riedel, Christian Heiner
Psychogios, Marios-Nikos
Brehm, Alex
Liman, Jan
von Arnim, Christine A. F.
author_sort Schnieder, Marlena
collection PubMed
description Frailty is associated with an increased risk of adverse health-care outcomes in elderly patients. The Hospital Frailty Risk Score (HFRS) has been developed and proven to be capable of identifying patients which are at high risk of adverse outcomes. We aimed to investigate whether frail patients also face adverse outcomes after experiencing an endovascular treated large vessel occlusion stroke (LVOS). In this retrospective observational cohort study, we analyzed patients ≥ 65 years that were admitted during 2015–2019 with LVOS and endovascular treatment. Primary outcomes were mortality and the modified Rankin Scale (mRS) after three months. Regression models were used to determine the impact of frailty. A total of 318 patients were included in the cohort. The median HFRS was 1.6 (IQR 4.8). A total of 238 (75.1%) patients fulfilled the criteria for a low-frailty risk with a HFRS < 5.72 (22.7%) for moderate-frailty risk with an HFRS from 5–15 and 7 (2.2%) patients for a high-frailty risk. Multivariate regression analyses revealed that the HFRS was associated with an increased mortality after 90 days (CI (95%) 1.001 to 1.236; OR 1.112) and a worse mRS (CI (95%) 1.004 to 1.270; OR 1.129). We identified frailty as an impact factor on functional outcome and mortality in patients undergoing thrombectomy in LVOS.
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spelling pubmed-81572682021-05-28 Analysis of Frailty in Geriatric Patients as a Prognostic Factor in Endovascular Treated Patients with Large Vessel Occlusion Strokes Schnieder, Marlena Bähr, Mathias Kirsch, Mareike Maier, Ilko Behme, Daniel Riedel, Christian Heiner Psychogios, Marios-Nikos Brehm, Alex Liman, Jan von Arnim, Christine A. F. J Clin Med Article Frailty is associated with an increased risk of adverse health-care outcomes in elderly patients. The Hospital Frailty Risk Score (HFRS) has been developed and proven to be capable of identifying patients which are at high risk of adverse outcomes. We aimed to investigate whether frail patients also face adverse outcomes after experiencing an endovascular treated large vessel occlusion stroke (LVOS). In this retrospective observational cohort study, we analyzed patients ≥ 65 years that were admitted during 2015–2019 with LVOS and endovascular treatment. Primary outcomes were mortality and the modified Rankin Scale (mRS) after three months. Regression models were used to determine the impact of frailty. A total of 318 patients were included in the cohort. The median HFRS was 1.6 (IQR 4.8). A total of 238 (75.1%) patients fulfilled the criteria for a low-frailty risk with a HFRS < 5.72 (22.7%) for moderate-frailty risk with an HFRS from 5–15 and 7 (2.2%) patients for a high-frailty risk. Multivariate regression analyses revealed that the HFRS was associated with an increased mortality after 90 days (CI (95%) 1.001 to 1.236; OR 1.112) and a worse mRS (CI (95%) 1.004 to 1.270; OR 1.129). We identified frailty as an impact factor on functional outcome and mortality in patients undergoing thrombectomy in LVOS. MDPI 2021-05-18 /pmc/articles/PMC8157268/ /pubmed/34069797 http://dx.doi.org/10.3390/jcm10102171 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Schnieder, Marlena
Bähr, Mathias
Kirsch, Mareike
Maier, Ilko
Behme, Daniel
Riedel, Christian Heiner
Psychogios, Marios-Nikos
Brehm, Alex
Liman, Jan
von Arnim, Christine A. F.
Analysis of Frailty in Geriatric Patients as a Prognostic Factor in Endovascular Treated Patients with Large Vessel Occlusion Strokes
title Analysis of Frailty in Geriatric Patients as a Prognostic Factor in Endovascular Treated Patients with Large Vessel Occlusion Strokes
title_full Analysis of Frailty in Geriatric Patients as a Prognostic Factor in Endovascular Treated Patients with Large Vessel Occlusion Strokes
title_fullStr Analysis of Frailty in Geriatric Patients as a Prognostic Factor in Endovascular Treated Patients with Large Vessel Occlusion Strokes
title_full_unstemmed Analysis of Frailty in Geriatric Patients as a Prognostic Factor in Endovascular Treated Patients with Large Vessel Occlusion Strokes
title_short Analysis of Frailty in Geriatric Patients as a Prognostic Factor in Endovascular Treated Patients with Large Vessel Occlusion Strokes
title_sort analysis of frailty in geriatric patients as a prognostic factor in endovascular treated patients with large vessel occlusion strokes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157268/
https://www.ncbi.nlm.nih.gov/pubmed/34069797
http://dx.doi.org/10.3390/jcm10102171
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