Generation of TIM3 inhibitory single-domain antibodies to boost the antitumor activity of chimeric antigen receptor T cells

Targeting inhibitory immune checkpoint molecules has significantly altered cancer treatment regimens. T cell immunoglobulin and mucin domain 3 (TIM3) is one of the major inhibitory immune checkpoints expressed on T cells. Blocking the engagement of TIM3 and its inhibitory ligand galectin-9 may poten...

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Detalles Bibliográficos
Autores principales: Yang, Liu, Chen, Xin, Wang, Qian, Zhu, Yuankui, Wu, Changfa, Ma, Xuqian, Zuo, Dianbao, He, Huixia, Huang, Le, Li, Jingwen, Xia, Chunjiao, Hu, Sheng, Yang, Xiaoqing, Feng, Mingqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157332/
https://www.ncbi.nlm.nih.gov/pubmed/34079595
http://dx.doi.org/10.3892/ol.2021.12803

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