Synthesis and Evaluation of Some Uracil Nucleosides as Promising Anti-Herpes Simplex Virus 1 Agents

Since herpes simplex virus type 1 (HSV-1) infection is so widespread, several antiviral drugs have been developed to treat it, among which are uracil nucleosides. However, there are major problems with the current medications such as severe side-effects and drug resistance. Here we present some newl...

Descripción completa

Detalles Bibliográficos
Autores principales: Awad, Samir Mohamed, Ali, Shima Mahmoud, Mansour, Yara Essam, Fatahala, Samar Said
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157375/
https://www.ncbi.nlm.nih.gov/pubmed/34069874
http://dx.doi.org/10.3390/molecules26102988
_version_ 1783699669527822336
author Awad, Samir Mohamed
Ali, Shima Mahmoud
Mansour, Yara Essam
Fatahala, Samar Said
author_facet Awad, Samir Mohamed
Ali, Shima Mahmoud
Mansour, Yara Essam
Fatahala, Samar Said
author_sort Awad, Samir Mohamed
collection PubMed
description Since herpes simplex virus type 1 (HSV-1) infection is so widespread, several antiviral drugs have been developed to treat it, among which are uracil nucleosides. However, there are major problems with the current medications such as severe side-effects and drug resistance. Here we present some newly synthesized cyclic and acyclic uracil nucleosides that showed very promising activity against HSV-1 compared to acyclovir.
format Online
Article
Text
id pubmed-8157375
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-81573752021-05-28 Synthesis and Evaluation of Some Uracil Nucleosides as Promising Anti-Herpes Simplex Virus 1 Agents Awad, Samir Mohamed Ali, Shima Mahmoud Mansour, Yara Essam Fatahala, Samar Said Molecules Article Since herpes simplex virus type 1 (HSV-1) infection is so widespread, several antiviral drugs have been developed to treat it, among which are uracil nucleosides. However, there are major problems with the current medications such as severe side-effects and drug resistance. Here we present some newly synthesized cyclic and acyclic uracil nucleosides that showed very promising activity against HSV-1 compared to acyclovir. MDPI 2021-05-18 /pmc/articles/PMC8157375/ /pubmed/34069874 http://dx.doi.org/10.3390/molecules26102988 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Awad, Samir Mohamed
Ali, Shima Mahmoud
Mansour, Yara Essam
Fatahala, Samar Said
Synthesis and Evaluation of Some Uracil Nucleosides as Promising Anti-Herpes Simplex Virus 1 Agents
title Synthesis and Evaluation of Some Uracil Nucleosides as Promising Anti-Herpes Simplex Virus 1 Agents
title_full Synthesis and Evaluation of Some Uracil Nucleosides as Promising Anti-Herpes Simplex Virus 1 Agents
title_fullStr Synthesis and Evaluation of Some Uracil Nucleosides as Promising Anti-Herpes Simplex Virus 1 Agents
title_full_unstemmed Synthesis and Evaluation of Some Uracil Nucleosides as Promising Anti-Herpes Simplex Virus 1 Agents
title_short Synthesis and Evaluation of Some Uracil Nucleosides as Promising Anti-Herpes Simplex Virus 1 Agents
title_sort synthesis and evaluation of some uracil nucleosides as promising anti-herpes simplex virus 1 agents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157375/
https://www.ncbi.nlm.nih.gov/pubmed/34069874
http://dx.doi.org/10.3390/molecules26102988
work_keys_str_mv AT awadsamirmohamed synthesisandevaluationofsomeuracilnucleosidesaspromisingantiherpessimplexvirus1agents
AT alishimamahmoud synthesisandevaluationofsomeuracilnucleosidesaspromisingantiherpessimplexvirus1agents
AT mansouryaraessam synthesisandevaluationofsomeuracilnucleosidesaspromisingantiherpessimplexvirus1agents
AT fatahalasamarsaid synthesisandevaluationofsomeuracilnucleosidesaspromisingantiherpessimplexvirus1agents

Ejemplares similares