A palladium-catalyzed C–H functionalization route to ketones via the oxidative coupling of arenes with carbon monoxide

We describe the development of a new palladium-catalyzed method to generate ketones via the oxidative coupling of two arenes and CO. This transformation is catalyzed by simple palladium salts, and is postulated to proceed via the conversion of arenes into high energy aroyl triflate electrophiles. Ex...

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Autores principales: Levesque, Taleah M., Kinney, R. Garrison, Arndtsen, Bruce A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157493/
https://www.ncbi.nlm.nih.gov/pubmed/34122815
http://dx.doi.org/10.1039/d0sc00085j
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author Levesque, Taleah M.
Kinney, R. Garrison
Arndtsen, Bruce A.
author_facet Levesque, Taleah M.
Kinney, R. Garrison
Arndtsen, Bruce A.
author_sort Levesque, Taleah M.
collection PubMed
description We describe the development of a new palladium-catalyzed method to generate ketones via the oxidative coupling of two arenes and CO. This transformation is catalyzed by simple palladium salts, and is postulated to proceed via the conversion of arenes into high energy aroyl triflate electrophiles. Exploiting the latter can also allow the synthesis of unsymmetrical ketones from two different arenes.
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spelling pubmed-81574932021-06-11 A palladium-catalyzed C–H functionalization route to ketones via the oxidative coupling of arenes with carbon monoxide Levesque, Taleah M. Kinney, R. Garrison Arndtsen, Bruce A. Chem Sci Chemistry We describe the development of a new palladium-catalyzed method to generate ketones via the oxidative coupling of two arenes and CO. This transformation is catalyzed by simple palladium salts, and is postulated to proceed via the conversion of arenes into high energy aroyl triflate electrophiles. Exploiting the latter can also allow the synthesis of unsymmetrical ketones from two different arenes. The Royal Society of Chemistry 2020-02-20 /pmc/articles/PMC8157493/ /pubmed/34122815 http://dx.doi.org/10.1039/d0sc00085j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Levesque, Taleah M.
Kinney, R. Garrison
Arndtsen, Bruce A.
A palladium-catalyzed C–H functionalization route to ketones via the oxidative coupling of arenes with carbon monoxide
title A palladium-catalyzed C–H functionalization route to ketones via the oxidative coupling of arenes with carbon monoxide
title_full A palladium-catalyzed C–H functionalization route to ketones via the oxidative coupling of arenes with carbon monoxide
title_fullStr A palladium-catalyzed C–H functionalization route to ketones via the oxidative coupling of arenes with carbon monoxide
title_full_unstemmed A palladium-catalyzed C–H functionalization route to ketones via the oxidative coupling of arenes with carbon monoxide
title_short A palladium-catalyzed C–H functionalization route to ketones via the oxidative coupling of arenes with carbon monoxide
title_sort palladium-catalyzed c–h functionalization route to ketones via the oxidative coupling of arenes with carbon monoxide
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157493/
https://www.ncbi.nlm.nih.gov/pubmed/34122815
http://dx.doi.org/10.1039/d0sc00085j
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