Catalytic enantioselective arylative cyclizations of alkynyl 1,3-diketones by 1,4-rhodium(i) migration

The enantioselective synthesis of densely functionalized polycarbocycles by the rhodium(i)-catalyzed reaction of arylboronic acids with 1,3-diketones is described. The key step in these desymmetrizing domino addition–cyclization reactions is an alkenyl-to-aryl 1,4-Rh(i) migration, which enables aryl...

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Detalles Bibliográficos
Autores principales: Groves, Alistair, Sun, Jinwei, Parke, Hal R. I., Callingham, Michael, Argent, Stephen P., Taylor, Laurence J., Lam, Hon Wai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157494/
https://www.ncbi.nlm.nih.gov/pubmed/34084335
http://dx.doi.org/10.1039/c9sc06309a
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author Groves, Alistair
Sun, Jinwei
Parke, Hal R. I.
Callingham, Michael
Argent, Stephen P.
Taylor, Laurence J.
Lam, Hon Wai
author_facet Groves, Alistair
Sun, Jinwei
Parke, Hal R. I.
Callingham, Michael
Argent, Stephen P.
Taylor, Laurence J.
Lam, Hon Wai
author_sort Groves, Alistair
collection PubMed
description The enantioselective synthesis of densely functionalized polycarbocycles by the rhodium(i)-catalyzed reaction of arylboronic acids with 1,3-diketones is described. The key step in these desymmetrizing domino addition–cyclization reactions is an alkenyl-to-aryl 1,4-Rh(i) migration, which enables arylboronic acids to function effectively as 1,2-dimetalloarene surrogates.
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spelling pubmed-81574942021-06-02 Catalytic enantioselective arylative cyclizations of alkynyl 1,3-diketones by 1,4-rhodium(i) migration Groves, Alistair Sun, Jinwei Parke, Hal R. I. Callingham, Michael Argent, Stephen P. Taylor, Laurence J. Lam, Hon Wai Chem Sci Chemistry The enantioselective synthesis of densely functionalized polycarbocycles by the rhodium(i)-catalyzed reaction of arylboronic acids with 1,3-diketones is described. The key step in these desymmetrizing domino addition–cyclization reactions is an alkenyl-to-aryl 1,4-Rh(i) migration, which enables arylboronic acids to function effectively as 1,2-dimetalloarene surrogates. The Royal Society of Chemistry 2020-02-06 /pmc/articles/PMC8157494/ /pubmed/34084335 http://dx.doi.org/10.1039/c9sc06309a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Groves, Alistair
Sun, Jinwei
Parke, Hal R. I.
Callingham, Michael
Argent, Stephen P.
Taylor, Laurence J.
Lam, Hon Wai
Catalytic enantioselective arylative cyclizations of alkynyl 1,3-diketones by 1,4-rhodium(i) migration
title Catalytic enantioselective arylative cyclizations of alkynyl 1,3-diketones by 1,4-rhodium(i) migration
title_full Catalytic enantioselective arylative cyclizations of alkynyl 1,3-diketones by 1,4-rhodium(i) migration
title_fullStr Catalytic enantioselective arylative cyclizations of alkynyl 1,3-diketones by 1,4-rhodium(i) migration
title_full_unstemmed Catalytic enantioselective arylative cyclizations of alkynyl 1,3-diketones by 1,4-rhodium(i) migration
title_short Catalytic enantioselective arylative cyclizations of alkynyl 1,3-diketones by 1,4-rhodium(i) migration
title_sort catalytic enantioselective arylative cyclizations of alkynyl 1,3-diketones by 1,4-rhodium(i) migration
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157494/
https://www.ncbi.nlm.nih.gov/pubmed/34084335
http://dx.doi.org/10.1039/c9sc06309a
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