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Palmitoylethanolamide: A Natural Compound for Health Management
All nations which have undergone a nutrition transition have experienced increased frequency and falling latency of chronic degenerative diseases, which are largely driven by chronic inflammatory stress. Dietary supplementation is a valid strategy to reduce the risk and severity of such disorders. P...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157570/ https://www.ncbi.nlm.nih.gov/pubmed/34069940 http://dx.doi.org/10.3390/ijms22105305 |
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author | Clayton, Paul Hill, Mariko Bogoda, Nathasha Subah, Silma Venkatesh, Ruchitha |
author_facet | Clayton, Paul Hill, Mariko Bogoda, Nathasha Subah, Silma Venkatesh, Ruchitha |
author_sort | Clayton, Paul |
collection | PubMed |
description | All nations which have undergone a nutrition transition have experienced increased frequency and falling latency of chronic degenerative diseases, which are largely driven by chronic inflammatory stress. Dietary supplementation is a valid strategy to reduce the risk and severity of such disorders. Palmitoylethanolamide (PEA) is an endocannabinoid-like lipid mediator with extensively documented anti-inflammatory, analgesic, antimicrobial, immunomodulatory and neuroprotective effects. It is well tolerated and devoid of side effects in animals and humans. PEA’s actions on multiple molecular targets while modulating multiple inflammatory mediators provide therapeutic benefits in many applications, including immunity, brain health, allergy, pain modulation, joint health, sleep and recovery. PEA’s poor oral bioavailability, a major obstacle in early research, has been overcome by advanced delivery systems now licensed as food supplements. This review summarizes the functionality of PEA, supporting its use as an important dietary supplement for lifestyle management. |
format | Online Article Text |
id | pubmed-8157570 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81575702021-05-28 Palmitoylethanolamide: A Natural Compound for Health Management Clayton, Paul Hill, Mariko Bogoda, Nathasha Subah, Silma Venkatesh, Ruchitha Int J Mol Sci Review All nations which have undergone a nutrition transition have experienced increased frequency and falling latency of chronic degenerative diseases, which are largely driven by chronic inflammatory stress. Dietary supplementation is a valid strategy to reduce the risk and severity of such disorders. Palmitoylethanolamide (PEA) is an endocannabinoid-like lipid mediator with extensively documented anti-inflammatory, analgesic, antimicrobial, immunomodulatory and neuroprotective effects. It is well tolerated and devoid of side effects in animals and humans. PEA’s actions on multiple molecular targets while modulating multiple inflammatory mediators provide therapeutic benefits in many applications, including immunity, brain health, allergy, pain modulation, joint health, sleep and recovery. PEA’s poor oral bioavailability, a major obstacle in early research, has been overcome by advanced delivery systems now licensed as food supplements. This review summarizes the functionality of PEA, supporting its use as an important dietary supplement for lifestyle management. MDPI 2021-05-18 /pmc/articles/PMC8157570/ /pubmed/34069940 http://dx.doi.org/10.3390/ijms22105305 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Clayton, Paul Hill, Mariko Bogoda, Nathasha Subah, Silma Venkatesh, Ruchitha Palmitoylethanolamide: A Natural Compound for Health Management |
title | Palmitoylethanolamide: A Natural Compound for Health Management |
title_full | Palmitoylethanolamide: A Natural Compound for Health Management |
title_fullStr | Palmitoylethanolamide: A Natural Compound for Health Management |
title_full_unstemmed | Palmitoylethanolamide: A Natural Compound for Health Management |
title_short | Palmitoylethanolamide: A Natural Compound for Health Management |
title_sort | palmitoylethanolamide: a natural compound for health management |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157570/ https://www.ncbi.nlm.nih.gov/pubmed/34069940 http://dx.doi.org/10.3390/ijms22105305 |
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