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Palmitoylethanolamide: A Natural Compound for Health Management

All nations which have undergone a nutrition transition have experienced increased frequency and falling latency of chronic degenerative diseases, which are largely driven by chronic inflammatory stress. Dietary supplementation is a valid strategy to reduce the risk and severity of such disorders. P...

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Autores principales: Clayton, Paul, Hill, Mariko, Bogoda, Nathasha, Subah, Silma, Venkatesh, Ruchitha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157570/
https://www.ncbi.nlm.nih.gov/pubmed/34069940
http://dx.doi.org/10.3390/ijms22105305
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author Clayton, Paul
Hill, Mariko
Bogoda, Nathasha
Subah, Silma
Venkatesh, Ruchitha
author_facet Clayton, Paul
Hill, Mariko
Bogoda, Nathasha
Subah, Silma
Venkatesh, Ruchitha
author_sort Clayton, Paul
collection PubMed
description All nations which have undergone a nutrition transition have experienced increased frequency and falling latency of chronic degenerative diseases, which are largely driven by chronic inflammatory stress. Dietary supplementation is a valid strategy to reduce the risk and severity of such disorders. Palmitoylethanolamide (PEA) is an endocannabinoid-like lipid mediator with extensively documented anti-inflammatory, analgesic, antimicrobial, immunomodulatory and neuroprotective effects. It is well tolerated and devoid of side effects in animals and humans. PEA’s actions on multiple molecular targets while modulating multiple inflammatory mediators provide therapeutic benefits in many applications, including immunity, brain health, allergy, pain modulation, joint health, sleep and recovery. PEA’s poor oral bioavailability, a major obstacle in early research, has been overcome by advanced delivery systems now licensed as food supplements. This review summarizes the functionality of PEA, supporting its use as an important dietary supplement for lifestyle management.
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spelling pubmed-81575702021-05-28 Palmitoylethanolamide: A Natural Compound for Health Management Clayton, Paul Hill, Mariko Bogoda, Nathasha Subah, Silma Venkatesh, Ruchitha Int J Mol Sci Review All nations which have undergone a nutrition transition have experienced increased frequency and falling latency of chronic degenerative diseases, which are largely driven by chronic inflammatory stress. Dietary supplementation is a valid strategy to reduce the risk and severity of such disorders. Palmitoylethanolamide (PEA) is an endocannabinoid-like lipid mediator with extensively documented anti-inflammatory, analgesic, antimicrobial, immunomodulatory and neuroprotective effects. It is well tolerated and devoid of side effects in animals and humans. PEA’s actions on multiple molecular targets while modulating multiple inflammatory mediators provide therapeutic benefits in many applications, including immunity, brain health, allergy, pain modulation, joint health, sleep and recovery. PEA’s poor oral bioavailability, a major obstacle in early research, has been overcome by advanced delivery systems now licensed as food supplements. This review summarizes the functionality of PEA, supporting its use as an important dietary supplement for lifestyle management. MDPI 2021-05-18 /pmc/articles/PMC8157570/ /pubmed/34069940 http://dx.doi.org/10.3390/ijms22105305 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Clayton, Paul
Hill, Mariko
Bogoda, Nathasha
Subah, Silma
Venkatesh, Ruchitha
Palmitoylethanolamide: A Natural Compound for Health Management
title Palmitoylethanolamide: A Natural Compound for Health Management
title_full Palmitoylethanolamide: A Natural Compound for Health Management
title_fullStr Palmitoylethanolamide: A Natural Compound for Health Management
title_full_unstemmed Palmitoylethanolamide: A Natural Compound for Health Management
title_short Palmitoylethanolamide: A Natural Compound for Health Management
title_sort palmitoylethanolamide: a natural compound for health management
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157570/
https://www.ncbi.nlm.nih.gov/pubmed/34069940
http://dx.doi.org/10.3390/ijms22105305
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