Insulin Resistance and Diabetes Mellitus in Alzheimer’s Disease

Type 2 diabetes mellitus is a progressive disease that is characterized by the appearance of insulin resistance. The term insulin resistance is very wide and could affect different proteins involved in insulin signaling, as well as other mechanisms. In this review, we have analyzed the main molecula...

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Autores principales: Burillo, Jesús, Marqués, Patricia, Jiménez, Beatriz, González-Blanco, Carlos, Benito, Manuel, Guillén, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157600/
https://www.ncbi.nlm.nih.gov/pubmed/34069890
http://dx.doi.org/10.3390/cells10051236
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author Burillo, Jesús
Marqués, Patricia
Jiménez, Beatriz
González-Blanco, Carlos
Benito, Manuel
Guillén, Carlos
author_facet Burillo, Jesús
Marqués, Patricia
Jiménez, Beatriz
González-Blanco, Carlos
Benito, Manuel
Guillén, Carlos
author_sort Burillo, Jesús
collection PubMed
description Type 2 diabetes mellitus is a progressive disease that is characterized by the appearance of insulin resistance. The term insulin resistance is very wide and could affect different proteins involved in insulin signaling, as well as other mechanisms. In this review, we have analyzed the main molecular mechanisms that could be involved in the connection between type 2 diabetes and neurodegeneration, in general, and more specifically with the appearance of Alzheimer’s disease. We have studied, in more detail, the different processes involved, such as inflammation, endoplasmic reticulum stress, autophagy, and mitochondrial dysfunction.
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spelling pubmed-81576002021-05-28 Insulin Resistance and Diabetes Mellitus in Alzheimer’s Disease Burillo, Jesús Marqués, Patricia Jiménez, Beatriz González-Blanco, Carlos Benito, Manuel Guillén, Carlos Cells Review Type 2 diabetes mellitus is a progressive disease that is characterized by the appearance of insulin resistance. The term insulin resistance is very wide and could affect different proteins involved in insulin signaling, as well as other mechanisms. In this review, we have analyzed the main molecular mechanisms that could be involved in the connection between type 2 diabetes and neurodegeneration, in general, and more specifically with the appearance of Alzheimer’s disease. We have studied, in more detail, the different processes involved, such as inflammation, endoplasmic reticulum stress, autophagy, and mitochondrial dysfunction. MDPI 2021-05-18 /pmc/articles/PMC8157600/ /pubmed/34069890 http://dx.doi.org/10.3390/cells10051236 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Burillo, Jesús
Marqués, Patricia
Jiménez, Beatriz
González-Blanco, Carlos
Benito, Manuel
Guillén, Carlos
Insulin Resistance and Diabetes Mellitus in Alzheimer’s Disease
title Insulin Resistance and Diabetes Mellitus in Alzheimer’s Disease
title_full Insulin Resistance and Diabetes Mellitus in Alzheimer’s Disease
title_fullStr Insulin Resistance and Diabetes Mellitus in Alzheimer’s Disease
title_full_unstemmed Insulin Resistance and Diabetes Mellitus in Alzheimer’s Disease
title_short Insulin Resistance and Diabetes Mellitus in Alzheimer’s Disease
title_sort insulin resistance and diabetes mellitus in alzheimer’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157600/
https://www.ncbi.nlm.nih.gov/pubmed/34069890
http://dx.doi.org/10.3390/cells10051236
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