Association of Alpha B-Crystallin Expression with Tumor Differentiation Grade in Colorectal Cancer Patients

Alpha B-crystallin (CRYAB, HSPB5) belongs to the small heat shock protein (HSP) family and is highly expressed in various human cancers, suggesting a crucial role in tumor progression. However, few studies have examined CRYAB expression in colorectal cancer (CRC). In the present study, we investigat...

Descripción completa

Detalles Bibliográficos
Autores principales: Pagano, Cristina, Navarra, Giovanna, Gazzerro, Patrizia, Vitale, Mario, Notarnicola, Maria, Caruso, Maria Gabriella, Cavalcanti, Elisabetta, Armentano, Raffaele, Laezza, Chiara, Bifulco, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157605/
https://www.ncbi.nlm.nih.gov/pubmed/34069924
http://dx.doi.org/10.3390/diagnostics11050896
Descripción
Sumario:Alpha B-crystallin (CRYAB, HSPB5) belongs to the small heat shock protein (HSP) family and is highly expressed in various human cancers, suggesting a crucial role in tumor progression. However, few studies have examined CRYAB expression in colorectal cancer (CRC). In the present study, we investigated the relationship between CRYAB expression and the clinicopathological features of CRC samples. We comparatively analyzed CRYAB protein expression in 111 CRC tissues and normal adjacent colonic tissue, observing that it was significantly lower in CRC tissues than in corresponding non-cancerous tissues. Moreover, immunohistochemical analysis showed a significant correlation between CRYAB expression and high histological grade G3 (p = 0.033). In summary, our results point to its possible application as a prognostic biomarker in CRC patients.

Ejemplares similares