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Association of Alpha B-Crystallin Expression with Tumor Differentiation Grade in Colorectal Cancer Patients
Alpha B-crystallin (CRYAB, HSPB5) belongs to the small heat shock protein (HSP) family and is highly expressed in various human cancers, suggesting a crucial role in tumor progression. However, few studies have examined CRYAB expression in colorectal cancer (CRC). In the present study, we investigat...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157605/ https://www.ncbi.nlm.nih.gov/pubmed/34069924 http://dx.doi.org/10.3390/diagnostics11050896 |
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author | Pagano, Cristina Navarra, Giovanna Gazzerro, Patrizia Vitale, Mario Notarnicola, Maria Caruso, Maria Gabriella Cavalcanti, Elisabetta Armentano, Raffaele Laezza, Chiara Bifulco, Maurizio |
author_facet | Pagano, Cristina Navarra, Giovanna Gazzerro, Patrizia Vitale, Mario Notarnicola, Maria Caruso, Maria Gabriella Cavalcanti, Elisabetta Armentano, Raffaele Laezza, Chiara Bifulco, Maurizio |
author_sort | Pagano, Cristina |
collection | PubMed |
description | Alpha B-crystallin (CRYAB, HSPB5) belongs to the small heat shock protein (HSP) family and is highly expressed in various human cancers, suggesting a crucial role in tumor progression. However, few studies have examined CRYAB expression in colorectal cancer (CRC). In the present study, we investigated the relationship between CRYAB expression and the clinicopathological features of CRC samples. We comparatively analyzed CRYAB protein expression in 111 CRC tissues and normal adjacent colonic tissue, observing that it was significantly lower in CRC tissues than in corresponding non-cancerous tissues. Moreover, immunohistochemical analysis showed a significant correlation between CRYAB expression and high histological grade G3 (p = 0.033). In summary, our results point to its possible application as a prognostic biomarker in CRC patients. |
format | Online Article Text |
id | pubmed-8157605 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81576052021-05-28 Association of Alpha B-Crystallin Expression with Tumor Differentiation Grade in Colorectal Cancer Patients Pagano, Cristina Navarra, Giovanna Gazzerro, Patrizia Vitale, Mario Notarnicola, Maria Caruso, Maria Gabriella Cavalcanti, Elisabetta Armentano, Raffaele Laezza, Chiara Bifulco, Maurizio Diagnostics (Basel) Brief Report Alpha B-crystallin (CRYAB, HSPB5) belongs to the small heat shock protein (HSP) family and is highly expressed in various human cancers, suggesting a crucial role in tumor progression. However, few studies have examined CRYAB expression in colorectal cancer (CRC). In the present study, we investigated the relationship between CRYAB expression and the clinicopathological features of CRC samples. We comparatively analyzed CRYAB protein expression in 111 CRC tissues and normal adjacent colonic tissue, observing that it was significantly lower in CRC tissues than in corresponding non-cancerous tissues. Moreover, immunohistochemical analysis showed a significant correlation between CRYAB expression and high histological grade G3 (p = 0.033). In summary, our results point to its possible application as a prognostic biomarker in CRC patients. MDPI 2021-05-18 /pmc/articles/PMC8157605/ /pubmed/34069924 http://dx.doi.org/10.3390/diagnostics11050896 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report Pagano, Cristina Navarra, Giovanna Gazzerro, Patrizia Vitale, Mario Notarnicola, Maria Caruso, Maria Gabriella Cavalcanti, Elisabetta Armentano, Raffaele Laezza, Chiara Bifulco, Maurizio Association of Alpha B-Crystallin Expression with Tumor Differentiation Grade in Colorectal Cancer Patients |
title | Association of Alpha B-Crystallin Expression with Tumor Differentiation Grade in Colorectal Cancer Patients |
title_full | Association of Alpha B-Crystallin Expression with Tumor Differentiation Grade in Colorectal Cancer Patients |
title_fullStr | Association of Alpha B-Crystallin Expression with Tumor Differentiation Grade in Colorectal Cancer Patients |
title_full_unstemmed | Association of Alpha B-Crystallin Expression with Tumor Differentiation Grade in Colorectal Cancer Patients |
title_short | Association of Alpha B-Crystallin Expression with Tumor Differentiation Grade in Colorectal Cancer Patients |
title_sort | association of alpha b-crystallin expression with tumor differentiation grade in colorectal cancer patients |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157605/ https://www.ncbi.nlm.nih.gov/pubmed/34069924 http://dx.doi.org/10.3390/diagnostics11050896 |
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