The contribution of Lynch syndrome to early onset malignancy in Ireland

BACKGROUND: Lynch syndrome (LS) is an autosomal dominant hereditary cancer syndrome responsible for 2–4% of hereditary colorectal cancers (CRC). Mismatch repair protein deficiency (dMMR) is a characteristic feature of LS. It has been associated with a poor response to standard chemotherapy in metast...

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Detalles Bibliográficos
Autores principales: Talbot, Alice, O’Donovan, Emily, Berkley, Eileen, Nolan, Carmel, Clarke, Roisin, Gallagher, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157691/
https://www.ncbi.nlm.nih.gov/pubmed/34039291
http://dx.doi.org/10.1186/s12885-021-08263-z

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