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Exercise training and de-training effects on serum leptin and TNF-α in high fat induced diabetic rats

BACKGROUND: Adipocytokines, which are secreted by the adipose tissue, contribute to the pathogenesis of obesity-related complications. To evaluate this assumption, we investigated the effects of aerobic exercise training (AET), resistance exercise training (RET), and 4 weeks of de-training on serum...

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Autores principales: Dinari Ghozhdi, Hamideh, Heidarianpour, Ali, Keshvari, Maryam, Tavassoli, Hassan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157711/
https://www.ncbi.nlm.nih.gov/pubmed/34039404
http://dx.doi.org/10.1186/s13098-021-00676-x
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author Dinari Ghozhdi, Hamideh
Heidarianpour, Ali
Keshvari, Maryam
Tavassoli, Hassan
author_facet Dinari Ghozhdi, Hamideh
Heidarianpour, Ali
Keshvari, Maryam
Tavassoli, Hassan
author_sort Dinari Ghozhdi, Hamideh
collection PubMed
description BACKGROUND: Adipocytokines, which are secreted by the adipose tissue, contribute to the pathogenesis of obesity-related complications. To evaluate this assumption, we investigated the effects of aerobic exercise training (AET), resistance exercise training (RET), and 4 weeks of de-training on serum leptin and TNF-α levels in diabetic rats. METHOD: 36 Wistar rats were divided into normal diet (ND) (control, RET, AET) and high-fat diet (HFD) + STZ (control, RET, AET) groups. Serum insulin, leptin, and TNF-α levels were assessed by commercial ELISA kits. Also fasting blood glucose (FBG), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) levels were measured by the colorimetric kits. RESULTS: Diabetes induction increased body weight (BW) and FBG, and decreased insulin compared to the ND rats’ groups (p < 0.001). 12-weeks of AET and RET programs in the trained diabetic rats led to a decrease in TG, LDL-C, leptin, TNF-α, and FBG, and an increase in insulin compared to the HFD + STZ-C group (p < 0.001). Besides, there was no difference between AET and RET in improving the variables studied (p > 0.05). Also, de-training led to increased BW, TG, leptin, and TNF-α compared to the end of the exercise training (p < 0.05). The correlation between the variables studied was established at different stages of the study (p < 0.05), and only BW was not correlated with insulin during exercise training and de-training (p > 0.05). CONCLUSION: These findings indicate that both AET and RET are useful in reducing levels of serum adipocytokines (TNF-α, leptin) in diabetic and non-diabetic rats. At the same time, 4 weeks of de-training was sufficient to lose the metabolic adaptations.
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spelling pubmed-81577112021-05-28 Exercise training and de-training effects on serum leptin and TNF-α in high fat induced diabetic rats Dinari Ghozhdi, Hamideh Heidarianpour, Ali Keshvari, Maryam Tavassoli, Hassan Diabetol Metab Syndr Research BACKGROUND: Adipocytokines, which are secreted by the adipose tissue, contribute to the pathogenesis of obesity-related complications. To evaluate this assumption, we investigated the effects of aerobic exercise training (AET), resistance exercise training (RET), and 4 weeks of de-training on serum leptin and TNF-α levels in diabetic rats. METHOD: 36 Wistar rats were divided into normal diet (ND) (control, RET, AET) and high-fat diet (HFD) + STZ (control, RET, AET) groups. Serum insulin, leptin, and TNF-α levels were assessed by commercial ELISA kits. Also fasting blood glucose (FBG), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) levels were measured by the colorimetric kits. RESULTS: Diabetes induction increased body weight (BW) and FBG, and decreased insulin compared to the ND rats’ groups (p < 0.001). 12-weeks of AET and RET programs in the trained diabetic rats led to a decrease in TG, LDL-C, leptin, TNF-α, and FBG, and an increase in insulin compared to the HFD + STZ-C group (p < 0.001). Besides, there was no difference between AET and RET in improving the variables studied (p > 0.05). Also, de-training led to increased BW, TG, leptin, and TNF-α compared to the end of the exercise training (p < 0.05). The correlation between the variables studied was established at different stages of the study (p < 0.05), and only BW was not correlated with insulin during exercise training and de-training (p > 0.05). CONCLUSION: These findings indicate that both AET and RET are useful in reducing levels of serum adipocytokines (TNF-α, leptin) in diabetic and non-diabetic rats. At the same time, 4 weeks of de-training was sufficient to lose the metabolic adaptations. BioMed Central 2021-05-26 /pmc/articles/PMC8157711/ /pubmed/34039404 http://dx.doi.org/10.1186/s13098-021-00676-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Dinari Ghozhdi, Hamideh
Heidarianpour, Ali
Keshvari, Maryam
Tavassoli, Hassan
Exercise training and de-training effects on serum leptin and TNF-α in high fat induced diabetic rats
title Exercise training and de-training effects on serum leptin and TNF-α in high fat induced diabetic rats
title_full Exercise training and de-training effects on serum leptin and TNF-α in high fat induced diabetic rats
title_fullStr Exercise training and de-training effects on serum leptin and TNF-α in high fat induced diabetic rats
title_full_unstemmed Exercise training and de-training effects on serum leptin and TNF-α in high fat induced diabetic rats
title_short Exercise training and de-training effects on serum leptin and TNF-α in high fat induced diabetic rats
title_sort exercise training and de-training effects on serum leptin and tnf-α in high fat induced diabetic rats
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157711/
https://www.ncbi.nlm.nih.gov/pubmed/34039404
http://dx.doi.org/10.1186/s13098-021-00676-x
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