Cargando…

The Food Contaminants Pyrrolizidine Alkaloids Disturb Bile Acid Homeostasis Structure-Dependently in the Human Hepatoma Cell Line HepaRG

Pyrrolizidine alkaloids (PAs) are a group of secondary plant metabolites being contained in various plant species. The consumption of contaminated food can lead to acute intoxications in humans and exert severe hepatotoxicity. The development of jaundice and elevated bile acid concentrations in bloo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Glück, Josephin, Henricsson, Marcus, Braeuning, Albert, Hessel-Pras, Stefanie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157858/ https://www.ncbi.nlm.nih.gov/pubmed/34069968 http://dx.doi.org/10.3390/foods10051114

Ejemplares similares

Pyrrolizidine Alkaloids Disturb Bile Acid Homeostasis in the Human Hepatoma Cell Line HepaRG
por: Waizenegger, Julia, et al.
Publicado: (2021)

Pyrrolizidine Alkaloids Induce Cell Death in Human HepaRG Cells in a Structure-Dependent Manner
por: Glück, Josephin, et al.
Publicado: (2020)

Active Transport of Hepatotoxic Pyrrolizidine Alkaloids in HepaRG Cells
por: Enge, Anne-Margarethe, et al.
Publicado: (2021)

Toxic Prediction of Pyrrolizidine Alkaloids and Structure-Dependent Induction of Apoptosis in HepaRG Cells
por: Zheng, Pimiao, et al.
Publicado: (2021)

Identification of microRNAs Implicated in Modulating Senecionine-Induced Liver Toxicity in HepaRG Cells
por: Enge, Anne-Margarethe, et al.
Publicado: (2022)

Impairment of bile acid metabolism by perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) in human HepaRG hepatoma cells
por: Behr, Anne-Cathrin, et al.
Publicado: (2020)

Functional polarization of human hepatoma HepaRG cells in response to forskolin
por: Mayati, Abdullah, et al.
Publicado: (2018)

Okadaic acid influences xenobiotic metabolism in HepaRG cells
por: Wuerger, Leonie T.D., et al.
Publicado: (2022)

mRNA Expression and Activity of Nucleoside Transporters in Human Hepatoma HepaRG Cells
por: Mayati, Abdullah, et al.
Publicado: (2018)

RNA-protein correlation of liver toxicity markers in HepaRG cells
por: Braeuning, Albert, et al.
Publicado: (2020)

Structure-Dependent Toxicokinetics of Selected Pyrrolizidine Alkaloids In Vitro
por: Buchmueller, Julia, et al.
Publicado: (2022)

Inhibition of canalicular and sinusoidal taurocholate efflux by cholestatic drugs in human hepatoma HepaRG cells
por: Le Vée, Marc, et al.
Publicado: (2022)

Proteomic analysis of hepatic effects of okadaic acid in HepaRG human liver cells
por: Wuerger, Leonie T.D., et al.
Publicado: (2023)

Okadaic Acid Activates JAK/STAT Signaling to Affect Xenobiotic Metabolism in HepaRG Cells
por: Wuerger, Leonie T. D., et al.
Publicado: (2023)

Evaluation of the impact of matrix stiffness on encapsulated HepaRG spheroids
por: Rebelo, Sofia P, et al.
Publicado: (2013)

Evaluation of a novel PXR‐knockout in HepaRG(™) cells
por: Williamson, Beth, et al.
Publicado: (2016)

Transcriptional and Epigenetic Consequences of DMSO Treatment on HepaRG Cells
por: Dubois-Pot-Schneider, Hélène, et al.
Publicado: (2022)

Differential toxic effects of bile acid mixtures in isolated mitochondria and physiologically relevant HepaRG cells
por: Penman, Sophie L., et al.
Publicado: (2019)

More than additive effects on liver triglyceride accumulation by combinations of steatotic and non-steatotic pesticides in HepaRG cells
por: Lasch, Alexandra, et al.
Publicado: (2021)

Comparative Analysis of Transcriptional Responses to Genotoxic and Non-Genotoxic Agents in the Blood Cell Model TK6 and the Liver Model HepaRG
por: Kreuzer, Katrin, et al.
Publicado: (2022)

Hepatotropic Peptides Grafted onto Maleimide-Decorated Nanoparticles: Preparation, Characterization and In Vitro Uptake by Human HepaRG Hepatoma Cells
por: Brossard, Clarisse, et al.
Publicado: (2022)

Testing chemical carcinogenicity by using a transcriptomics HepaRG-based model?
por: Doktorova, T. Y., et al.
Publicado: (2014)

Global transcriptomic profiling of microcystin-LR or -RR treated hepatocytes (HepaRG)
por: Biales, Adam D., et al.
Publicado: (2020)

The Effects of Naringenin on miRNA-mRNA Profiles in HepaRG Cells
por: Fan, Weiyang, et al.
Publicado: (2021)

Quantitative understanding of HepaRG cells during drug‐induced intrahepatic cholestasis through changes in bile canaliculi dynamics
por: Sonoi, Rie, et al.
Publicado: (2022)

Proteomic analysis of plasma membranes isolated from undifferentiated and differentiated HepaRG cells
por: Sokolowska, Izabela, et al.
Publicado: (2012)

Analysis of Mitochondrial DNA Polymorphisms in the Human Cell Lines HepaRG and SJCRH30
por: Young, Matthew J., et al.
Publicado: (2019)

Improved human hematopoietic reconstitution in HepaRG co-transplanted humanized NSG mice
por: Kim, Jin, et al.
Publicado: (2020)

The Hepatotoxicity of Alantolactone and Germacrone: Their Influence on Cholesterol and Lipid Metabolism in Differentiated HepaRG Cells
por: Zárybnický, Tomáš, et al.
Publicado: (2020)

Fast Differentiation of HepaRG Cells Allowing Hepatitis B and Delta Virus Infections
por: Lucifora, Julie, et al.
Publicado: (2020)

A first experience of transduction for differentiated HepaRG cells using lentiviral technology
por: Pivert, Adeline, et al.
Publicado: (2019)

Automated Analysis of Acetaminophen Toxicity on 3D HepaRG Cell Culture in Microbioreactor
por: Baca, Martin, et al.
Publicado: (2022)

Hepatotoxic pyrrolizidine alkaloids induce DNA damage response in rat liver in a 28-day feeding study
por: Ebmeyer, Johanna, et al.
Publicado: (2020)

Comparison of Human Hepatoma HepaRG Cells with Human and Rat Hepatocytes in Uptake Transport Assays in Order to Predict a Risk of Drug Induced Hepatotoxicity
por: Szabo, Monika, et al.
Publicado: (2013)

Pyrrolizidine alkaloid-induced transcriptomic changes in rat lungs in a 28-day subacute feeding study
por: Buchmueller, Julia, et al.
Publicado: (2021)

3D spheroid cultures improve the metabolic gene expression profiles of HepaRG cells
por: Takahashi, Yu, et al.
Publicado: (2015)

Triptolide Induces Apoptosis Through Fas Death and Mitochondrial Pathways in HepaRG Cell Line
por: You, Longtai, et al.
Publicado: (2018)

The histone deacetylase inhibiting drug Entinostat induces lipid accumulation in differentiated HepaRG cells
por: Nunn, Abigail D. G., et al.
Publicado: (2016)

A high throughput imaging database of toxicological effects of nanomaterials tested on HepaRG cells
por: Joossens, Elisabeth, et al.
Publicado: (2019)

The Performance of HepG2 and HepaRG Systems through the Glass of Acetaminophen-Induced Toxicity
por: Lőrincz, Tamás, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_bdk57tif1micvq3fr5pada4gri