Dopaminergic Receptor Targeting in Multiple Sclerosis: Is There Therapeutic Potential?

Dopamine is a neurotransmitter that mediates neuropsychological functions of the central nervous system (CNS). Recent studies have shown the modulatory effect of dopamine on the cells of innate and adaptive immune systems, including Th17 cells, which play a critical role in inflammatory diseases of...

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Detalles Bibliográficos
Autores principales: Melnikov, Mikhail, Pashenkov, Mikhail, Boyko, Alexey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157879/
https://www.ncbi.nlm.nih.gov/pubmed/34070011
http://dx.doi.org/10.3390/ijms22105313
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author Melnikov, Mikhail
Pashenkov, Mikhail
Boyko, Alexey
author_facet Melnikov, Mikhail
Pashenkov, Mikhail
Boyko, Alexey
author_sort Melnikov, Mikhail
collection PubMed
description Dopamine is a neurotransmitter that mediates neuropsychological functions of the central nervous system (CNS). Recent studies have shown the modulatory effect of dopamine on the cells of innate and adaptive immune systems, including Th17 cells, which play a critical role in inflammatory diseases of the CNS. This article reviews the literature data on the role of dopamine in the regulation of neuroinflammation in multiple sclerosis (MS). The influence of dopaminergic receptor targeting on experimental autoimmune encephalomyelitis (EAE) and MS pathogenesis, as well as the therapeutic potential of dopaminergic drugs as add-on pathogenetic therapy of MS, is discussed.
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spelling pubmed-81578792021-05-28 Dopaminergic Receptor Targeting in Multiple Sclerosis: Is There Therapeutic Potential? Melnikov, Mikhail Pashenkov, Mikhail Boyko, Alexey Int J Mol Sci Opinion Dopamine is a neurotransmitter that mediates neuropsychological functions of the central nervous system (CNS). Recent studies have shown the modulatory effect of dopamine on the cells of innate and adaptive immune systems, including Th17 cells, which play a critical role in inflammatory diseases of the CNS. This article reviews the literature data on the role of dopamine in the regulation of neuroinflammation in multiple sclerosis (MS). The influence of dopaminergic receptor targeting on experimental autoimmune encephalomyelitis (EAE) and MS pathogenesis, as well as the therapeutic potential of dopaminergic drugs as add-on pathogenetic therapy of MS, is discussed. MDPI 2021-05-18 /pmc/articles/PMC8157879/ /pubmed/34070011 http://dx.doi.org/10.3390/ijms22105313 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Opinion
Melnikov, Mikhail
Pashenkov, Mikhail
Boyko, Alexey
Dopaminergic Receptor Targeting in Multiple Sclerosis: Is There Therapeutic Potential?
title Dopaminergic Receptor Targeting in Multiple Sclerosis: Is There Therapeutic Potential?
title_full Dopaminergic Receptor Targeting in Multiple Sclerosis: Is There Therapeutic Potential?
title_fullStr Dopaminergic Receptor Targeting in Multiple Sclerosis: Is There Therapeutic Potential?
title_full_unstemmed Dopaminergic Receptor Targeting in Multiple Sclerosis: Is There Therapeutic Potential?
title_short Dopaminergic Receptor Targeting in Multiple Sclerosis: Is There Therapeutic Potential?
title_sort dopaminergic receptor targeting in multiple sclerosis: is there therapeutic potential?
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157879/
https://www.ncbi.nlm.nih.gov/pubmed/34070011
http://dx.doi.org/10.3390/ijms22105313
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AT pashenkovmikhail dopaminergicreceptortargetinginmultiplesclerosisistheretherapeuticpotential
AT boykoalexey dopaminergicreceptortargetinginmultiplesclerosisistheretherapeuticpotential

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