Physiological concentrations of cyanide stimulate mitochondrial Complex IV and enhance cellular bioenergetics

In mammalian cells, cyanide is viewed as a cytotoxic agent, which exerts its effects through inhibition of mitochondrial Complex IV (Cytochrome C oxidase [CCOx]). However, the current report demonstrates that cyanide’s effect on CCOx is biphasic; low (nanomolar to low-micromolar) concentrations stim...

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Detalles Bibliográficos
Autores principales: Randi, Elisa B., Zuhra, Karim, Pecze, Laszlo, Panagaki, Theodora, Szabo, Csaba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157914/
https://www.ncbi.nlm.nih.gov/pubmed/33972444
http://dx.doi.org/10.1073/pnas.2026245118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157914/
https://www.ncbi.nlm.nih.gov/pubmed/33972444
http://dx.doi.org/10.1073/pnas.2026245118

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