AGO2 promotes tumor progression in KRAS-driven mouse models of non–small cell lung cancer

Lung cancer is the deadliest malignancy in the United States. Non–small cell lung cancer (NSCLC) accounts for 85% of cases and is frequently driven by activating mutations in the gene encoding the KRAS GTPase (e.g., KRASG12D). Our previous work demonstrated that Argonaute 2 (AGO2)—a component of the...

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Detalles Bibliográficos
Autores principales: Tien, Jean Ching-Yi, Chugh, Seema, Goodrum, Andrew E., Cheng, Yunhui, Mannan, Rahul, Zhang, Yuping, Wang, Lisha, Dommeti, Vijaya L., Wang, Xiaoming, Xu, Alice, Hon, Jennifer, Kenum, Carson, Su, Fengyun, Wang, Rui, Cao, Xuhong, Shankar, Sunita, Chinnaiyan, Arul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157917/
https://www.ncbi.nlm.nih.gov/pubmed/33972443
http://dx.doi.org/10.1073/pnas.2026104118

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