Cargando…

Development of Pelubiprofen Tromethamine with Improved Gastrointestinal Safety and Absorption

Pelubiprofen (PEL), which is a commercialized non-steroidal anti-inflammatory drug (NSAID), is associated with the risk of gastrointestinal (GI) adverse events following long-term exposure and has poor water-soluble properties. Here, a new pelubiprofen tromethamine (PEL-T) with improved solubility,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Park, Ji Yeon, Oh, Dong Ho, Park, Sang-Wook, Chae, Bo Ram, Kim, Chul Woo, Han, Sang Heon, Shin, Hyeon Jong, Yeom, Soo Bin, Lee, Da Yeong, Park, Min Kyu, Park, Sang-Eun, Park, Jun-Bom, Lee, Kyung-Tae
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158122/ https://www.ncbi.nlm.nih.gov/pubmed/34070062 http://dx.doi.org/10.3390/pharmaceutics13050745

Ejemplares similares

Pharmacokinetic and Pharmacodynamic Characteristics of Pelubiprofen Tromethamine vs. Pelubiprofen in Healthy Subjects
por: Son, Yu-Jeong, et al.
Publicado: (2023)

Eccrine Squamous Syringometaplasia Associated with Pelubiprofen Therapy
por: Huh, Joon Won, et al.
Publicado: (2017)

Comparison of the efficacy and safety profiles of a pelubiprofen versus celecoxib in patients with rheumatoid arthritis: a 6-week, multicenter, randomized, double-blind, phase III, non-inferiority clinical trial
por: Choi, In Ah, et al.
Publicado: (2014)

Sustained-release solid dispersion of pelubiprofen using the blended mixture of aminoclay and pH independent polymers: preparation and in vitro/in vivo characterization
por: Lee, Yeo-Song, et al.
Publicado: (2017)

A Case of Vanishing Bile Duct Syndrome after Drug-Induced Liver Injury Caused by Pelubiprofen
por: Bak, Haein, et al.
Publicado: (2020)

The effects of fluid absorption and plasma volume changes in athletes following consumption of various beverages
por: Yun, Hyo-Jun, et al.
Publicado: (2022)

Long-term Outcomes and Risk Factors for Reoperation After Surgical Treatment for Gastrointestinal Crohn Disease According to Anti-tumor Necrosis Factor-α Antibody Use: 35 Years of Experience at a Single Institute in Korea
por: Lee, Sang Mok, et al.
Publicado: (2015)

Serial evaluation of the serum lactate level with the SOFA score to predict mortality in patients with sepsis
por: Park, Heemoon, et al.
Publicado: (2023)

Predictors of Rebleeding in Upper Gastrointestinal Dieulafoy Lesions
por: Park, Sang-Hun, et al.
Publicado: (2015)

Enhanced Light Absorption and Efficient Carrier Collection in MoS(2) Monolayers on Au Nanopillars
por: Song, Jungeun, et al.
Publicado: (2022)

Effect of probiotic supplementation on gastrointestinal motility, inflammation, motor, non-motor symptoms and mental health in Parkinson’s disease: a meta-analysis of randomized controlled trials
por: Park, Jong Mi, et al.
Publicado: (2023)

Improved Bioavailability of Poorly Water-Soluble Drug by Targeting Increased Absorption through Solubility Enhancement and Precipitation Inhibition
por: Lee, Ju-Hyun, et al.
Publicado: (2021)

The Effects of Eupatilin (Stillen®) on Motility of Human Lower Gastrointestinal Tracts
por: Ryoo, Seung-Bum, et al.
Publicado: (2014)

A link between appendectomy and gastrointestinal cancers: a large-scale population-based cohort study in Korea
por: Park, Youn Young, et al.
Publicado: (2020)

Publisher Correction: A link between appendectomy and gastrointestinal cancers: a large-scale population-based cohort study in Korea
por: Park, Youn Young, et al.
Publicado: (2021)

Hemostatic powder application for control of acute upper gastrointestinal bleeding in patients with gastric malignancy
por: Kim, Yeong Jin, et al.
Publicado: (2018)

Failure of High-Flow Nasal Cannula Therapy in Pneumonia and Non-Pneumonia Sepsis Patients: A Prospective Cohort Study
por: Kim, Eunhye, et al.
Publicado: (2021)

1,3-Bis[(6-methyl-2-pyridyl)methyl]imidazolium bromide
por: Kim, Ga Young, et al.
Publicado: (2009)

Recent studies on flavonoids and their antioxidant activities
por: Chae, Soo Cheon, et al.
Publicado: (2013)

An Electronic Health Record-Integrated Computerized Intravenous Insulin Infusion Protocol: Clinical Outcomes and in Silico Adjustment
por: Park, Sung Woon, et al.
Publicado: (2020)

Response: An Electronic Health Record-Integrated Computerized Intravenous Insulin Infusion Protocol: Clinical Outcomes and in Silico Adjustment (Diabetes Metab J 2020;44:56–66)
por: Park, Sung Woon, et al.
Publicado: (2020)

The Association Between Tachycardia and Mortality in Septic Shock Patients According to Serum Lactate Level: A Nationwide Multicenter Cohort Study
por: Na, Soo Jin, et al.
Publicado: (2023)

Peritumoral lymphoid cuff correlates well with lymph node enlargement in gastrointestinal schwannomas
por: Bae, Hyunsik, et al.
Publicado: (2018)

Ocular pharmacokinetics of 0.45% ketorolac tromethamine
por: Attar, Mayssa, et al.
Publicado: (2010)

Ecological Effects of Benzyl Chloride on Different Korean Aquatic Indigenous Species Using an Artificial Stream Mesocosm Simulating a Chemical Spill
por: Kim, Soo-Yeon, et al.
Publicado: (2021)

Gintonin absorption in intestinal model systems
por: Lee, Byung-Hwan, et al.
Publicado: (2018)

Hydraulic Strategy of Cactus Trichome for Absorption and Storage of Water under Arid Environment
por: Kim, Kiwoong, et al.
Publicado: (2017)

Biomechanical comparison of anterior lumbar interbody fusion: stand-alone interbody cage versus interbody cage with pedicle screw fixation - a finite element analysis
por: Choi, Kyung-Chul, et al.
Publicado: (2013)

Kalopanacis Cortex extract-capped gold nanoparticles activate NRF2 signaling and ameliorate damage in human neuronal SH-SY5Y cells exposed to oxygen–glucose deprivation and reoxygenation
por: Park, Sun Young, et al.
Publicado: (2017)

X-ray PIV measurement of blood flow in deep vessels of a rat: An in vivo feasibility study
por: Park, Hanwook, et al.
Publicado: (2016)

Blood-sparing removal technique of extracorporeal membrane oxygenation circuit in a Jehovah Witness patient: Case report
por: Park, Sang Min, et al.
Publicado: (2019)

Falsely Elevated Postvoid Residual Urine Volume in Uterine Myoma
por: Kim, Tae Hee, et al.
Publicado: (2017)

Hidden Long Head of the Biceps Tendon Instability and Concealed Intratendinous Subscapularis Tears
por: Chae, Sang Hoon, et al.
Publicado: (2020)

Comparison of International Guidelines of Dermal Absorption Tests Used in Pesticides Exposure Assessment for Operators
por: So, Jaehwan, et al.
Publicado: (2014)

Are Clinically Insignificant Prostate Cancers Really Insignificant among Korean Men?
por: Yeom, Chan Dong, et al.
Publicado: (2012)

Design, synthesis, and study of novel phenethyl-based antitumor phospholipids downregulating p38 mitogen-activated protein kinase
por: Hassan, Ahmed H. E., et al.
Publicado: (2023)

The Use of Health Functional Foods in Gastrointestinal Cancer Patients
por: Kang, Hwa Pyoung, et al.
Publicado: (2013)

Association between the timing of ICU admission and mortality in patients with hospital-onset sepsis: a nationwide prospective cohort study
por: Ahn, Yoon Hae, et al.
Publicado: (2023)

Cholecystoduodenal fistula presenting with upper gastrointestinal bleeding: A case report
por: Park, Jin Myung, et al.
Publicado: (2021)

Second to fourth digit ratio: A predictor of adult lung function
por: Park, I-Nae, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_a3s8oiimv6g257rnpsf7k23v1m