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Drug-delivering devices in the urinary tract: A systematic review
OBJECTIVE: : To systematically review the use of drug-eluting stents (DES) and drug-coated balloons (DCB) in urology. MATERIALS AND METHODS: The systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. PubMed, Scopus, Web...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158184/ https://www.ncbi.nlm.nih.gov/pubmed/34104496 http://dx.doi.org/10.1080/2090598X.2021.1885948 |
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author | Kallidonis, Panagiotis Adamou, Constantinos Castillo, Sara Villarrova Liourdi, Despoina Liatsikos, Evangelos Lange, Dirk |
author_facet | Kallidonis, Panagiotis Adamou, Constantinos Castillo, Sara Villarrova Liourdi, Despoina Liatsikos, Evangelos Lange, Dirk |
author_sort | Kallidonis, Panagiotis |
collection | PubMed |
description | OBJECTIVE: : To systematically review the use of drug-eluting stents (DES) and drug-coated balloons (DCB) in urology. MATERIALS AND METHODS: The systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. PubMed, Scopus, Web of science and Cochrane Library online databases were searched in February 2019. Experimental and clinical studies, which included the placement of a DES or dilatation with DCB for investigating their potential use in the urinary tract for the management of ureteric or urethral pathologies, were included. The primary endpoint was to evaluate the current use of DES and DCB in urology. RESULTS: A total of 29 articles were included in the systematic review. A total of 10 studies tested DES or DCB containing anti-proliferative agents (paclitaxel, zotarolimus, sirolimus, halofugione). Antibiotic agent-containing DES were tested in nine studies (triclosan, quinolones, teicoplanin, nitrofurantoin, silver sulfadiazine). A total of eight studies investigated the release of anti-inflammatory agents by DES (ketorolac, indomethacin, EW-7197). Another group studied heparin-eluting stents. CONCLUSION: Despite the inconclusive outcomes of the three randomised controlled trials, drug-coated/eluting devices constitute a promising field in urology for the prevention of complications associated with conventional stents including pain and encrustation. Pre-clinical in vitro and in vivo studies have shown their ability to mitigate inflammation, inhibit re-stenosis and improve pain as indicated by declined use of anti-inflammatory drugs. Abbreviations: DES: drug-eluting stents; DCB: drug-coated balloons; DCS: drug-coated stents; HF: halofungione; MCP-1: monocyte chemoattractant protein 1; PRISMA, Preferred Reporting Items for Systematic Reviews and Meta-Analyses; PTCA: percutaneous transluminal coronary angioplasty; RANTES: regulated on activation, normal T-cell expressed and secreted; RCT: randomised controlled trial; USSQ, Ureteric Stent Symptoms Questionaire. |
format | Online Article Text |
id | pubmed-8158184 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-81581842021-06-07 Drug-delivering devices in the urinary tract: A systematic review Kallidonis, Panagiotis Adamou, Constantinos Castillo, Sara Villarrova Liourdi, Despoina Liatsikos, Evangelos Lange, Dirk Arab J Urol Uroscience OBJECTIVE: : To systematically review the use of drug-eluting stents (DES) and drug-coated balloons (DCB) in urology. MATERIALS AND METHODS: The systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. PubMed, Scopus, Web of science and Cochrane Library online databases were searched in February 2019. Experimental and clinical studies, which included the placement of a DES or dilatation with DCB for investigating their potential use in the urinary tract for the management of ureteric or urethral pathologies, were included. The primary endpoint was to evaluate the current use of DES and DCB in urology. RESULTS: A total of 29 articles were included in the systematic review. A total of 10 studies tested DES or DCB containing anti-proliferative agents (paclitaxel, zotarolimus, sirolimus, halofugione). Antibiotic agent-containing DES were tested in nine studies (triclosan, quinolones, teicoplanin, nitrofurantoin, silver sulfadiazine). A total of eight studies investigated the release of anti-inflammatory agents by DES (ketorolac, indomethacin, EW-7197). Another group studied heparin-eluting stents. CONCLUSION: Despite the inconclusive outcomes of the three randomised controlled trials, drug-coated/eluting devices constitute a promising field in urology for the prevention of complications associated with conventional stents including pain and encrustation. Pre-clinical in vitro and in vivo studies have shown their ability to mitigate inflammation, inhibit re-stenosis and improve pain as indicated by declined use of anti-inflammatory drugs. Abbreviations: DES: drug-eluting stents; DCB: drug-coated balloons; DCS: drug-coated stents; HF: halofungione; MCP-1: monocyte chemoattractant protein 1; PRISMA, Preferred Reporting Items for Systematic Reviews and Meta-Analyses; PTCA: percutaneous transluminal coronary angioplasty; RANTES: regulated on activation, normal T-cell expressed and secreted; RCT: randomised controlled trial; USSQ, Ureteric Stent Symptoms Questionaire. Taylor & Francis 2021-03-03 /pmc/articles/PMC8158184/ /pubmed/34104496 http://dx.doi.org/10.1080/2090598X.2021.1885948 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Uroscience Kallidonis, Panagiotis Adamou, Constantinos Castillo, Sara Villarrova Liourdi, Despoina Liatsikos, Evangelos Lange, Dirk Drug-delivering devices in the urinary tract: A systematic review |
title | Drug-delivering devices in the urinary tract: A systematic review |
title_full | Drug-delivering devices in the urinary tract: A systematic review |
title_fullStr | Drug-delivering devices in the urinary tract: A systematic review |
title_full_unstemmed | Drug-delivering devices in the urinary tract: A systematic review |
title_short | Drug-delivering devices in the urinary tract: A systematic review |
title_sort | drug-delivering devices in the urinary tract: a systematic review |
topic | Uroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158184/ https://www.ncbi.nlm.nih.gov/pubmed/34104496 http://dx.doi.org/10.1080/2090598X.2021.1885948 |
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