Novel chalcone/aryl carboximidamide hybrids as potent anti-inflammatory via inhibition of prostaglandin E2 and inducible NO synthase activities: design, synthesis, molecular docking studies and ADMET prediction

Two series of chalcone/aryl carboximidamide hybrids 4a–f and 6a–f were synthesised and evaluated for their inhibitory activity against iNOS and PGE2. The most potent derivatives were further checked for their in vivo anti-inflammatory activity utilising carrageenan-induced rat paw oedema model. Comp...

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Detalles Bibliográficos
Autores principales: Ibrahim, Tarek S., Moustafa, Amr H., Almalki, Ahmad J., Allam, Rasha M., Althagafi, Abdulhamid, Md, Shadab, Mohamed, Mamdouh F. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158245/
https://www.ncbi.nlm.nih.gov/pubmed/34027787
http://dx.doi.org/10.1080/14756366.2021.1929201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158245/
https://www.ncbi.nlm.nih.gov/pubmed/34027787
http://dx.doi.org/10.1080/14756366.2021.1929201

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