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Strategies to Build Hybrid Protein–DNA Nanostructures

Proteins and DNA exhibit key physical chemical properties that make them advantageous for building nanostructures with outstanding features. Both DNA and protein nanotechnology have growth notably and proved to be fertile disciplines. The combination of both types of nanotechnologies is helpful to o...

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Autor principal: Hernandez-Garcia, Armando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158336/
https://www.ncbi.nlm.nih.gov/pubmed/34070149
http://dx.doi.org/10.3390/nano11051332
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author Hernandez-Garcia, Armando
author_facet Hernandez-Garcia, Armando
author_sort Hernandez-Garcia, Armando
collection PubMed
description Proteins and DNA exhibit key physical chemical properties that make them advantageous for building nanostructures with outstanding features. Both DNA and protein nanotechnology have growth notably and proved to be fertile disciplines. The combination of both types of nanotechnologies is helpful to overcome the individual weaknesses and limitations of each one, paving the way for the continuing diversification of structural nanotechnologies. Recent studies have implemented a synergistic combination of both biomolecules to assemble unique and sophisticate protein–DNA nanostructures. These hybrid nanostructures are highly programmable and display remarkable features that create new opportunities to build on the nanoscale. This review focuses on the strategies deployed to create hybrid protein–DNA nanostructures. Here, we discuss strategies such as polymerization, spatial directing and organizing, coating, and rigidizing or folding DNA into particular shapes or moving parts. The enrichment of structural DNA nanotechnology by incorporating protein nanotechnology has been clearly demonstrated and still shows a large potential to create useful and advanced materials with cell-like properties or dynamic systems. It can be expected that structural protein–DNA nanotechnology will open new avenues in the fabrication of nanoassemblies with unique functional applications and enrich the toolbox of bionanotechnology.
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spelling pubmed-81583362021-05-28 Strategies to Build Hybrid Protein–DNA Nanostructures Hernandez-Garcia, Armando Nanomaterials (Basel) Review Proteins and DNA exhibit key physical chemical properties that make them advantageous for building nanostructures with outstanding features. Both DNA and protein nanotechnology have growth notably and proved to be fertile disciplines. The combination of both types of nanotechnologies is helpful to overcome the individual weaknesses and limitations of each one, paving the way for the continuing diversification of structural nanotechnologies. Recent studies have implemented a synergistic combination of both biomolecules to assemble unique and sophisticate protein–DNA nanostructures. These hybrid nanostructures are highly programmable and display remarkable features that create new opportunities to build on the nanoscale. This review focuses on the strategies deployed to create hybrid protein–DNA nanostructures. Here, we discuss strategies such as polymerization, spatial directing and organizing, coating, and rigidizing or folding DNA into particular shapes or moving parts. The enrichment of structural DNA nanotechnology by incorporating protein nanotechnology has been clearly demonstrated and still shows a large potential to create useful and advanced materials with cell-like properties or dynamic systems. It can be expected that structural protein–DNA nanotechnology will open new avenues in the fabrication of nanoassemblies with unique functional applications and enrich the toolbox of bionanotechnology. MDPI 2021-05-18 /pmc/articles/PMC8158336/ /pubmed/34070149 http://dx.doi.org/10.3390/nano11051332 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hernandez-Garcia, Armando
Strategies to Build Hybrid Protein–DNA Nanostructures
title Strategies to Build Hybrid Protein–DNA Nanostructures
title_full Strategies to Build Hybrid Protein–DNA Nanostructures
title_fullStr Strategies to Build Hybrid Protein–DNA Nanostructures
title_full_unstemmed Strategies to Build Hybrid Protein–DNA Nanostructures
title_short Strategies to Build Hybrid Protein–DNA Nanostructures
title_sort strategies to build hybrid protein–dna nanostructures
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158336/
https://www.ncbi.nlm.nih.gov/pubmed/34070149
http://dx.doi.org/10.3390/nano11051332
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