The Mutational Landscape of Acute Myeloid Leukaemia Predicts Responses and Outcomes in Elderly Patients from the PETHEMA-FLUGAZA Phase 3 Clinical Trial

SIMPLE SUMMARY: Mutational profiling using a custom 43-gene next-generation sequencing panel revealed that patients with mutated DNMT3A or EZH2, or an increase in TET2 VAF and lower TP53 VAF showed a higher overall response. NRAS and TP53 variants were associated with shorter overall survival (OS),...

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Detalles Bibliográficos
Autores principales: Ayala, Rosa, Rapado, Inmaculada, Onecha, Esther, Martínez-Cuadrón, David, Carreño-Tarragona, Gonzalo, Bergua, Juan Miguel, Vives, Susana, Algarra, Jesus Lorenzo, Tormo, Mar, Martinez, Pilar, Serrano, Josefina, Herrera, Pilar, Ramos, Fernando, Salamero, Olga, Lavilla, Esperanza, Gil, Cristina, López Lorenzo, Jose Luis, Vidriales, María Belén, Labrador, Jorge, Falantes, José Francisco, Sayas, María José, Paiva, Bruno, Barragán, Eva, Prosper, Felipe, Sanz, Miguel Ángel, Martínez-López, Joaquín, Montesinos, Pau
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158477/
https://www.ncbi.nlm.nih.gov/pubmed/34070172
http://dx.doi.org/10.3390/cancers13102458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158477/
https://www.ncbi.nlm.nih.gov/pubmed/34070172
http://dx.doi.org/10.3390/cancers13102458

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