Exploration of Blood Lipoprotein and Lipid Fraction Profiles in Healthy Subjects through Integrated Univariate, Multivariate, and Network Analysis Reveals Association of Lipase Activity and Cholesterol Esterification with Sex and Age

In this study, we investigated blood lipoprotein and lipid fraction profiles, quantified using nuclear magnetic resonance, in a cohort of 844 healthy blood donors, integrating standard univariate and multivariate analysis with predictive modeling and network analysis. We observed a strong associatio...

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Autores principales: Balder, Yasmijn, Vignoli, Alessia, Tenori, Leonardo, Luchinat, Claudio, Saccenti, Edoardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158518/
https://www.ncbi.nlm.nih.gov/pubmed/34070169
http://dx.doi.org/10.3390/metabo11050326
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author Balder, Yasmijn
Vignoli, Alessia
Tenori, Leonardo
Luchinat, Claudio
Saccenti, Edoardo
author_facet Balder, Yasmijn
Vignoli, Alessia
Tenori, Leonardo
Luchinat, Claudio
Saccenti, Edoardo
author_sort Balder, Yasmijn
collection PubMed
description In this study, we investigated blood lipoprotein and lipid fraction profiles, quantified using nuclear magnetic resonance, in a cohort of 844 healthy blood donors, integrating standard univariate and multivariate analysis with predictive modeling and network analysis. We observed a strong association of lipoprotein and lipid main fraction profiles with sex and age. Our results suggest an age-dependent remodulation of lipase lipoprotein activity in men and a change in the mechanisms controlling the ratio between esterified and non-esterified cholesterol in both men and women.
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spelling pubmed-81585182021-05-28 Exploration of Blood Lipoprotein and Lipid Fraction Profiles in Healthy Subjects through Integrated Univariate, Multivariate, and Network Analysis Reveals Association of Lipase Activity and Cholesterol Esterification with Sex and Age Balder, Yasmijn Vignoli, Alessia Tenori, Leonardo Luchinat, Claudio Saccenti, Edoardo Metabolites Article In this study, we investigated blood lipoprotein and lipid fraction profiles, quantified using nuclear magnetic resonance, in a cohort of 844 healthy blood donors, integrating standard univariate and multivariate analysis with predictive modeling and network analysis. We observed a strong association of lipoprotein and lipid main fraction profiles with sex and age. Our results suggest an age-dependent remodulation of lipase lipoprotein activity in men and a change in the mechanisms controlling the ratio between esterified and non-esterified cholesterol in both men and women. MDPI 2021-05-18 /pmc/articles/PMC8158518/ /pubmed/34070169 http://dx.doi.org/10.3390/metabo11050326 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Balder, Yasmijn
Vignoli, Alessia
Tenori, Leonardo
Luchinat, Claudio
Saccenti, Edoardo
Exploration of Blood Lipoprotein and Lipid Fraction Profiles in Healthy Subjects through Integrated Univariate, Multivariate, and Network Analysis Reveals Association of Lipase Activity and Cholesterol Esterification with Sex and Age
title Exploration of Blood Lipoprotein and Lipid Fraction Profiles in Healthy Subjects through Integrated Univariate, Multivariate, and Network Analysis Reveals Association of Lipase Activity and Cholesterol Esterification with Sex and Age
title_full Exploration of Blood Lipoprotein and Lipid Fraction Profiles in Healthy Subjects through Integrated Univariate, Multivariate, and Network Analysis Reveals Association of Lipase Activity and Cholesterol Esterification with Sex and Age
title_fullStr Exploration of Blood Lipoprotein and Lipid Fraction Profiles in Healthy Subjects through Integrated Univariate, Multivariate, and Network Analysis Reveals Association of Lipase Activity and Cholesterol Esterification with Sex and Age
title_full_unstemmed Exploration of Blood Lipoprotein and Lipid Fraction Profiles in Healthy Subjects through Integrated Univariate, Multivariate, and Network Analysis Reveals Association of Lipase Activity and Cholesterol Esterification with Sex and Age
title_short Exploration of Blood Lipoprotein and Lipid Fraction Profiles in Healthy Subjects through Integrated Univariate, Multivariate, and Network Analysis Reveals Association of Lipase Activity and Cholesterol Esterification with Sex and Age
title_sort exploration of blood lipoprotein and lipid fraction profiles in healthy subjects through integrated univariate, multivariate, and network analysis reveals association of lipase activity and cholesterol esterification with sex and age
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158518/
https://www.ncbi.nlm.nih.gov/pubmed/34070169
http://dx.doi.org/10.3390/metabo11050326
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