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Zebrafish and Flavonoids: Adjuvants against Obesity
Obesity is a pathological condition, defined as an excessive accumulation of fat, primarily caused by an energy imbalance. The storage of excess energy in the form of triglycerides within the adipocyte leads to lipotoxicity and promotes the phenotypic switch in the M1/M2 macrophage. These changes in...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158719/ https://www.ncbi.nlm.nih.gov/pubmed/34069388 http://dx.doi.org/10.3390/molecules26103014 |
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author | Montalbano, Giuseppe Mhalhel, Kamel Briglia, Marilena Levanti, Maria Abbate, Francesco Guerrera, Maria Cristina D’Alessandro, Enrico Laurà, Rosaria Germanà, Antonino |
author_facet | Montalbano, Giuseppe Mhalhel, Kamel Briglia, Marilena Levanti, Maria Abbate, Francesco Guerrera, Maria Cristina D’Alessandro, Enrico Laurà, Rosaria Germanà, Antonino |
author_sort | Montalbano, Giuseppe |
collection | PubMed |
description | Obesity is a pathological condition, defined as an excessive accumulation of fat, primarily caused by an energy imbalance. The storage of excess energy in the form of triglycerides within the adipocyte leads to lipotoxicity and promotes the phenotypic switch in the M1/M2 macrophage. These changes induce the development of a chronic state of low-grade inflammation, subsequently generating obesity-related complications, commonly known as metabolic syndromes. Over the past decade, obesity has been studied in many animal models. However, due to its competitive aspects and unique characteristics, the use of zebrafish has begun to gain traction in experimental obesity research. To counteract obesity and its related comorbidities, several natural substances have been studied. One of those natural substances reported to have substantial biological effects on obesity are flavonoids. This review summarizes the results of studies that examined the effects of flavonoids on obesity and related diseases and the emergence of zebrafish as a model of diet-induced obesity. |
format | Online Article Text |
id | pubmed-8158719 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81587192021-05-28 Zebrafish and Flavonoids: Adjuvants against Obesity Montalbano, Giuseppe Mhalhel, Kamel Briglia, Marilena Levanti, Maria Abbate, Francesco Guerrera, Maria Cristina D’Alessandro, Enrico Laurà, Rosaria Germanà, Antonino Molecules Review Obesity is a pathological condition, defined as an excessive accumulation of fat, primarily caused by an energy imbalance. The storage of excess energy in the form of triglycerides within the adipocyte leads to lipotoxicity and promotes the phenotypic switch in the M1/M2 macrophage. These changes induce the development of a chronic state of low-grade inflammation, subsequently generating obesity-related complications, commonly known as metabolic syndromes. Over the past decade, obesity has been studied in many animal models. However, due to its competitive aspects and unique characteristics, the use of zebrafish has begun to gain traction in experimental obesity research. To counteract obesity and its related comorbidities, several natural substances have been studied. One of those natural substances reported to have substantial biological effects on obesity are flavonoids. This review summarizes the results of studies that examined the effects of flavonoids on obesity and related diseases and the emergence of zebrafish as a model of diet-induced obesity. MDPI 2021-05-19 /pmc/articles/PMC8158719/ /pubmed/34069388 http://dx.doi.org/10.3390/molecules26103014 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Montalbano, Giuseppe Mhalhel, Kamel Briglia, Marilena Levanti, Maria Abbate, Francesco Guerrera, Maria Cristina D’Alessandro, Enrico Laurà, Rosaria Germanà, Antonino Zebrafish and Flavonoids: Adjuvants against Obesity |
title | Zebrafish and Flavonoids: Adjuvants against Obesity |
title_full | Zebrafish and Flavonoids: Adjuvants against Obesity |
title_fullStr | Zebrafish and Flavonoids: Adjuvants against Obesity |
title_full_unstemmed | Zebrafish and Flavonoids: Adjuvants against Obesity |
title_short | Zebrafish and Flavonoids: Adjuvants against Obesity |
title_sort | zebrafish and flavonoids: adjuvants against obesity |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158719/ https://www.ncbi.nlm.nih.gov/pubmed/34069388 http://dx.doi.org/10.3390/molecules26103014 |
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