Cargando…
Involvement of the Protein Ras Homolog Enriched in the Striatum, Rhes, in Dopaminergic Neurons’ Degeneration: Link to Parkinson’s Disease
Rhes is one of the most interesting genes regulated by thyroid hormones that, through the inhibition of the striatal cAMP/PKA pathway, acts as a modulator of dopamine neurotransmission. Rhes mRNA is expressed at high levels in the dorsal striatum, with a medial-to-lateral expression gradient reflect...
Autores principales: | Serra, Marcello, Pinna, Annalisa, Costa, Giulia, Usiello, Alessandro, Pasqualetti, Massimo, Avallone, Luigi, Morelli, Micaela, Napolitano, Francesco |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158741/ https://www.ncbi.nlm.nih.gov/pubmed/34070217 http://dx.doi.org/10.3390/ijms22105326 |
Ejemplares similares
-
Lack of Rhes Increases MDMA-Induced Neuroinflammation and Dopamine Neuron Degeneration: Role of Gender and Age
por: Costa, Giulia, et al.
Publicado: (2019) -
Rhes Counteracts Dopamine Neuron Degeneration and Neuroinflammation Depending on Gender and Age
por: Costa, Giulia, et al.
Publicado: (2018) -
Decreased Rhes mRNA levels in the brain of patients with Parkinson’s disease and MPTP-treated macaques
por: Napolitano, Francesco, et al.
Publicado: (2017) -
The striatal-enriched protein Rhes is a critical modulator of cocaine-induced molecular and behavioral responses
por: Napolitano, Francesco, et al.
Publicado: (2019) -
Rhes, a striatal–enriched small G–protein, mediates mTOR signaling and L–DOPA–induced dyskinesia
por: Subramaniam, Srinivasa, et al.
Publicado: (2011)