Cargando…

Synergistic Interaction between 5-FU and an Analog of Sulforaphane—2-Oxohexyl Isothiocyanate—In an In Vitro Colon Cancer Model

Combination therapy is based on the beneficial effects of pharmacodynamic interaction (synergistic or additive) between combined drugs or substances. A considerable group of candidates for combined treatments are natural compounds (e.g., isothiocyanates) and their analogs, which are tested in combin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Milczarek, Małgorzata, Pogorzelska, Anna, Wiktorska, Katarzyna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158758/ https://www.ncbi.nlm.nih.gov/pubmed/34069385 http://dx.doi.org/10.3390/molecules26103019

Ejemplares similares

In Vitro Evaluation of Sulforaphane and a Natural Analog as Potent Inducers of 5-Fluorouracil Anticancer Activity
por: Milczarek, Małgorzata, et al.
Publicado: (2018)

Breast Cancer Prevention-Is there a Future for Sulforaphane and Its Analogs?
por: Kuran, Dominika, et al.
Publicado: (2020)

An Organofluorine Isoselenocyanate Analogue of Sulforaphane Affects Antimetabolite 5-Fluorouracil’s Anticancer Activity: A Perspective for New Combinatory Therapy in Triple-Negative Breast Cancer
por: Milczarek, Małgorzata, et al.
Publicado: (2023)

Dietary Isothiocyanates, Sulforaphane and 2-Phenethyl Isothiocyanate, Effectively Impair Vibrio cholerae Virulence
por: Krause, Klaudyna, et al.
Publicado: (2021)

Sulforaphane (SFN): An Isothiocyanate in a Cancer Chemoprevention Paradigm
por: Ullah, Mohammad Fahad
Publicado: (2015)

The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner
por: Zhang, Ying, et al.
Publicado: (2021)

Various modes of action of dietary phytochemicals, sulforaphane and phenethyl isothiocyanate, on pathogenic bacteria
por: Nowicki, Dariusz, et al.
Publicado: (2019)

Comparative Effects of Sulforaphane and Allyl Isothiocyanate on 3T3-L1 Adipogenesis
por: Sakuma, Satoru, et al.
Publicado: (2022)

HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates
por: Rajendran, Praveen, et al.
Publicado: (2013)

Chemoprevention of oxidative stress-associated oral carcinogenesis by sulforaphane depends on NRF2 and the isothiocyanate moiety
por: Lan, Aixian, et al.
Publicado: (2016)

Monoclinic polymorph of 3,7-dimethyl-1-(5-oxohexyl)-3,7-dihydro-1H-purine-2,6-dione
por: Stepanovs, Dmitrijs, et al.
Publicado: (2011)

The Anti-Tumoral Potential of Phosphonate Analog of Sulforaphane in Zebrafish Xenograft Model
por: Rudzinska-Radecka, Magdalena, et al.
Publicado: (2021)

Synergistic Combinations of Curcumin, Sulforaphane, and Dihydrocaffeic Acid against Human Colon Cancer Cells
por: Santana-Gálvez, Jesús, et al.
Publicado: (2020)

Mono(2-ethyl-5-hydroxyhexyl) phthalate and mono-(2-ethyl-5-oxohexyl) phthalate as biomarkers for human exposure assessment to di-(2-ethylhexyl) phthalate.
por: Kato, Kayoko, et al.
Publicado: (2004)

Mechanism of acquired 5FU resistance and strategy for overcoming 5FU resistance focusing on 5FU metabolism in colon cancer cell lines
por: Suetsugu, Tomonari, et al.
Publicado: (2021)

Sulforaphane and Its Bifunctional Analogs: Synthesis and Biological Activity
por: Janczewski, Łukasz
Publicado: (2022)

Vitamin D analogs enhance the anticancer activity of 5-fluorouracil in an in vivo mouse colon cancer model
por: Milczarek, Magdalena, et al.
Publicado: (2013)

Vitamin D analogs combined with 5-fluorouracil in human HT-29 colon cancer treatment
por: MILCZAREK, MAGDALENA, et al.
Publicado: (2014)

The Mode of SN38 Derivatives Interacting with Nicked DNA Mimics Biological Targeting of Topo I Poisons
por: Bocian, Wojciech, et al.
Publicado: (2021)

Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery
por: De Angelis, Paula M, et al.
Publicado: (2006)

Cell Death Effects Induced by Sulforaphane and Allyl Isothiocyanate on P-Glycoprotein Positive and Negative Variants in L1210 Cells
por: Kontar, Szilvia, et al.
Publicado: (2020)

The Comparison of MTT and CVS Assays for the Assessment of Anticancer Agent Interactions
por: Śliwka, Lidia, et al.
Publicado: (2016)

HDAC6 inhibitor WT161 performs anti-tumor effect on osteosarcoma and synergistically interacts with 5-FU
por: Sun, Jun, et al.
Publicado: (2021)

A Lesson Learnt from Food Chemistry—Elevated Temperature Triggers the Antioxidant Action of Two Edible Isothiocyanates: Erucin and Sulforaphane
por: Cedrowski, Jakub, et al.
Publicado: (2020)

Insight on the Interaction between the Camptothecin Derivative and DNA Oligomer Mimicking the Target of Topo I Inhibitors
por: Bocian, Wojciech, et al.
Publicado: (2022)

Interaction of Sulforaphane with DNA and RNA
por: Abassi Joozdani, Farzaneh, et al.
Publicado: (2015)

5-FU Metabolism in Cancer and Orally-Administrable 5-FU Drugs
por: Miura, Koh, et al.
Publicado: (2010)

The dietary isothiocyanate sulforaphane modulates gene expression and alternative gene splicing in a PTEN null preclinical murine model of prostate cancer
por: Traka, Maria H, et al.
Publicado: (2010)

Metformin Inhibited Proliferation and Metastasis of Colorectal Cancer and presented a Synergistic Effect on 5-FU
por: Sang, Jing, et al.
Publicado: (2020)

The isothiocyanate sulforaphane induces respiratory burst oxidase homologue D‐dependent reactive oxygen species production and regulates expression of stress response genes
por: Arruebarrena Di Palma, Andrés, et al.
Publicado: (2022)

Neuroprotective potential of isothiocyanates in an in vitro model of neuroinflammation
por: Latronico, Tiziana, et al.
Publicado: (2020)

Evaluation of Anticancer Activity of Zhubech, a New 5-FU Analog Liposomal Formulation, against Pancreatic Cancer
por: Ndemazie, Nkafu Bechem, et al.
Publicado: (2023)

Dietary agent, benzyl isothiocyanate inhibits signal transducer and activator of transcription 3 phosphorylation and collaborates with sulforaphane in the growth suppression of PANC-1 cancer cells
por: Hutzen, Brian, et al.
Publicado: (2009)

Sulforaphane, a Natural Isothiocyanate Compound, Improves Cardiac Function and Remodeling by Inhibiting Oxidative Stress and Inflammation in a Rabbit Model of Chronic Heart Failure
por: Ma, Tongliang, et al.
Publicado: (2018)

Effectiveness of Adjuvant Chemotherapy with 5-FU/Leucovorin and Prognosis in Stage II Colon Cancer
por: Jee, Sun Hee, et al.
Publicado: (2011)

The Akt Inhibitor ISC-4 Synergizes with Cetuximab in 5-FU-Resistant Colon Cancer
por: Allen, Joshua E., et al.
Publicado: (2013)

PUMA mediates the combinational therapy of 5-FU and NVP-BEZ235 in colon cancer
por: Wang, Huanan, et al.
Publicado: (2015)

Over-expression of EGFR regulated by RARA contributes to 5-FU resistance in colon cancer
por: Gu, Xin-Yue, et al.
Publicado: (2020)

Sulforaphane and myricetin act synergistically to induce apoptosis in 3T3-L1 adipocytes
por: Yao, Anjun, et al.
Publicado: (2018)

Aspirin suppresses chemoresistance and enhances antitumor activity of 5-Fu in 5-Fu-resistant colorectal cancer by abolishing 5-Fu-induced NF-κB activation
por: Fu, Jinbo, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_2mp4l1jb4edecej3qii8b5c5si