Overall Retention of Methyl Stereochemistry during B(12)-Dependent Radical SAM Methyl Transfer in Fosfomycin Biosynthesis

[Image: see text] Methylcobalamin-dependent radical S-adenosylmethionine (SAM) enzymes methylate non-nucleophilic atoms in a range of substrates. The mechanism of the methyl transfer from cobalt to the receiving atom is still mostly unresolved. Here we determine the stereochemical course of this pro...

Descripción completa

Detalles Bibliográficos
Autores principales: McLaughlin, Martin I., Pallitsch, Katharina, Wallner, Gabriele, van der Donk, Wilfred A., Hammerschmidt, Friedrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158854/
https://www.ncbi.nlm.nih.gov/pubmed/33942609
http://dx.doi.org/10.1021/acs.biochem.1c00113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158854/
https://www.ncbi.nlm.nih.gov/pubmed/33942609
http://dx.doi.org/10.1021/acs.biochem.1c00113

Ejemplares similares