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Willingness to participate in COVID-19 vaccine trials; a survey among a population of healthcare workers in Uganda
BACKGROUND: Healthcare workers (HCWs) are at high risk of acquiring SARS-CoV-2 and COVID-19 and may therefore be a suitable population for COVID-19 vaccine trials. We conducted a survey to evaluate willingness-to-participate in COVID-19 vaccine trials in a population of HCWs at three hospitals in Ug...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158909/ https://www.ncbi.nlm.nih.gov/pubmed/34043693 http://dx.doi.org/10.1371/journal.pone.0251992 |
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author | Kitonsa, Jonathan Kamacooko, Onesmus Bahemuka, Ubaldo Mushabe Kibengo, Freddie Kakande, Ayoub Wajja, Anne Basajja, Vincent Lumala, Alfred Ssemwanga, Edward Asaba, Robert Mugisha, Joseph Pierce, Benjamin F. Shattock, Robin Kaleebu, Pontiano Ruzagira, Eugene |
author_facet | Kitonsa, Jonathan Kamacooko, Onesmus Bahemuka, Ubaldo Mushabe Kibengo, Freddie Kakande, Ayoub Wajja, Anne Basajja, Vincent Lumala, Alfred Ssemwanga, Edward Asaba, Robert Mugisha, Joseph Pierce, Benjamin F. Shattock, Robin Kaleebu, Pontiano Ruzagira, Eugene |
author_sort | Kitonsa, Jonathan |
collection | PubMed |
description | BACKGROUND: Healthcare workers (HCWs) are at high risk of acquiring SARS-CoV-2 and COVID-19 and may therefore be a suitable population for COVID-19 vaccine trials. We conducted a survey to evaluate willingness-to-participate in COVID-19 vaccine trials in a population of HCWs at three hospitals in Uganda. METHODS: The survey was conducted between September and November 2020. Using a standardised questionnaire, data were collected on socio-demographics, previous participation in health research, COVID-19 information sources, underlying health conditions, and willingness-to-participate in COVID-19 vaccine trials. Data were analysed descriptively and a binomial generalised linear model with a log link function used to investigate factors associated with unwillingness to participate. RESULTS: 657 HCWs (female, 63%) were enrolled with a mean age of 33 years (Standard Deviation, 10). Overall willingness-to-participate was 70.2%. Key motivating factors for participation were: hope of being protected against COVID-19 (81.1%), altruism (73.3%), and the opportunity to get health care (26.0%). Selected hypothetical trial attributes reduced willingness-to-participate as follows: weekly-quarterly study visits over a 12-month period (70.2%-63.2%, P = 0.026); provision of approximately 50ml of blood at each study visit (70.2%-63.2%, P = 0.026); risk of mild-moderate local adverse reactions (70.2%-60.3%, P<0.001); chance of receiving candidate vaccine or placebo (70.2%-56.9%, P<0.001); and delay of pregnancy [Overall, 70.2%-57.1% P<0.001); Female, 62.8%-48.4% (P = 0.002); Male, 82.5%-71.5% (P = 0.003)]. Collectively, these attributes reduced willingness-to-participate from [70.2%-42.2% (P<0.001) overall; 82.5%-58.1% (P<0.001) in men; 62.8%-32.6% (P<0.001) in women]. Among individuals that were unwilling to participate, the commonest barriers were concerns over vaccine safety (54.6%) and fear of catching SARS-CoV-2 (31.6%). Unwillingness to participate was associated with being female (aRR 1.97, CI 1.46–2.67, P<0.001) and having university or other higher-level education (aRR 1.52, CI 1.05–2.2, P = 0.026). CONCLUSIONS: Willingness-to-participate in COVID-19 vaccine trials among HCWs in Uganda is high but may be affected by vaccine trial requirements and concerns about the safety of candidate vaccines. |
format | Online Article Text |
id | pubmed-8158909 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-81589092021-06-09 Willingness to participate in COVID-19 vaccine trials; a survey among a population of healthcare workers in Uganda Kitonsa, Jonathan Kamacooko, Onesmus Bahemuka, Ubaldo Mushabe Kibengo, Freddie Kakande, Ayoub Wajja, Anne Basajja, Vincent Lumala, Alfred Ssemwanga, Edward Asaba, Robert Mugisha, Joseph Pierce, Benjamin F. Shattock, Robin Kaleebu, Pontiano Ruzagira, Eugene PLoS One Research Article BACKGROUND: Healthcare workers (HCWs) are at high risk of acquiring SARS-CoV-2 and COVID-19 and may therefore be a suitable population for COVID-19 vaccine trials. We conducted a survey to evaluate willingness-to-participate in COVID-19 vaccine trials in a population of HCWs at three hospitals in Uganda. METHODS: The survey was conducted between September and November 2020. Using a standardised questionnaire, data were collected on socio-demographics, previous participation in health research, COVID-19 information sources, underlying health conditions, and willingness-to-participate in COVID-19 vaccine trials. Data were analysed descriptively and a binomial generalised linear model with a log link function used to investigate factors associated with unwillingness to participate. RESULTS: 657 HCWs (female, 63%) were enrolled with a mean age of 33 years (Standard Deviation, 10). Overall willingness-to-participate was 70.2%. Key motivating factors for participation were: hope of being protected against COVID-19 (81.1%), altruism (73.3%), and the opportunity to get health care (26.0%). Selected hypothetical trial attributes reduced willingness-to-participate as follows: weekly-quarterly study visits over a 12-month period (70.2%-63.2%, P = 0.026); provision of approximately 50ml of blood at each study visit (70.2%-63.2%, P = 0.026); risk of mild-moderate local adverse reactions (70.2%-60.3%, P<0.001); chance of receiving candidate vaccine or placebo (70.2%-56.9%, P<0.001); and delay of pregnancy [Overall, 70.2%-57.1% P<0.001); Female, 62.8%-48.4% (P = 0.002); Male, 82.5%-71.5% (P = 0.003)]. Collectively, these attributes reduced willingness-to-participate from [70.2%-42.2% (P<0.001) overall; 82.5%-58.1% (P<0.001) in men; 62.8%-32.6% (P<0.001) in women]. Among individuals that were unwilling to participate, the commonest barriers were concerns over vaccine safety (54.6%) and fear of catching SARS-CoV-2 (31.6%). Unwillingness to participate was associated with being female (aRR 1.97, CI 1.46–2.67, P<0.001) and having university or other higher-level education (aRR 1.52, CI 1.05–2.2, P = 0.026). CONCLUSIONS: Willingness-to-participate in COVID-19 vaccine trials among HCWs in Uganda is high but may be affected by vaccine trial requirements and concerns about the safety of candidate vaccines. Public Library of Science 2021-05-27 /pmc/articles/PMC8158909/ /pubmed/34043693 http://dx.doi.org/10.1371/journal.pone.0251992 Text en © 2021 Kitonsa et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Kitonsa, Jonathan Kamacooko, Onesmus Bahemuka, Ubaldo Mushabe Kibengo, Freddie Kakande, Ayoub Wajja, Anne Basajja, Vincent Lumala, Alfred Ssemwanga, Edward Asaba, Robert Mugisha, Joseph Pierce, Benjamin F. Shattock, Robin Kaleebu, Pontiano Ruzagira, Eugene Willingness to participate in COVID-19 vaccine trials; a survey among a population of healthcare workers in Uganda |
title | Willingness to participate in COVID-19 vaccine trials; a survey among a population of healthcare workers in Uganda |
title_full | Willingness to participate in COVID-19 vaccine trials; a survey among a population of healthcare workers in Uganda |
title_fullStr | Willingness to participate in COVID-19 vaccine trials; a survey among a population of healthcare workers in Uganda |
title_full_unstemmed | Willingness to participate in COVID-19 vaccine trials; a survey among a population of healthcare workers in Uganda |
title_short | Willingness to participate in COVID-19 vaccine trials; a survey among a population of healthcare workers in Uganda |
title_sort | willingness to participate in covid-19 vaccine trials; a survey among a population of healthcare workers in uganda |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158909/ https://www.ncbi.nlm.nih.gov/pubmed/34043693 http://dx.doi.org/10.1371/journal.pone.0251992 |
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