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Adverse Childhood Experiences Predict Early Initiation of Opioid Use Behaviors

Introduction: Although a substantial body of research documents a relationship between traumatic stress in childhood and the initiation of substance use later in the life course, only limited research has examined potential linkages between adverse childhood experiences (ACEs) and the initiation of...

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Autores principales: Guarino, Honoria, Mateu-Gelabert, Pedro, Quinn, Kelly, Sirikantraporn, Skultip, Ruggles, Kelly V., Syckes, Cassandra, Goodbody, Elizabeth, Jessell, Lauren, Friedman, Samuel R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158934/
https://www.ncbi.nlm.nih.gov/pubmed/34055961
http://dx.doi.org/10.3389/fsoc.2021.620395
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author Guarino, Honoria
Mateu-Gelabert, Pedro
Quinn, Kelly
Sirikantraporn, Skultip
Ruggles, Kelly V.
Syckes, Cassandra
Goodbody, Elizabeth
Jessell, Lauren
Friedman, Samuel R.
author_facet Guarino, Honoria
Mateu-Gelabert, Pedro
Quinn, Kelly
Sirikantraporn, Skultip
Ruggles, Kelly V.
Syckes, Cassandra
Goodbody, Elizabeth
Jessell, Lauren
Friedman, Samuel R.
author_sort Guarino, Honoria
collection PubMed
description Introduction: Although a substantial body of research documents a relationship between traumatic stress in childhood and the initiation of substance use later in the life course, only limited research has examined potential linkages between adverse childhood experiences (ACEs) and the initiation of non-medical prescription opioid use and other opioid use behaviors. The present study contributes to this growing body of work by investigating the association of childhood trauma with early initiation of a series of opioid use behaviors. Methods: New York City young adults (n = 539) ages 18–29 who reported non-medical use of prescription opioids or heroin use in the past 30 days were recruited using Respondent-Driven Sampling in 2014–16. Ten ACEs were assessed via self-report with the ACE Questionnaire. Associations between number of ACEs and self-reported ages of initiating seven opioid use behaviors (e.g., non-medical prescription opioid use, heroin use, heroin injection) were estimated with multivariable logistic regression. Results: Eighty nine percent of participants reported at least one ACE, and 46% reported four or more ACEs, a well-supported threshold indicating elevated risk for negative health consequences. Every increase of one trauma was associated with a 12–23% increase in odds of early initiation across the seven opioid use behaviors. Findings also document that the mean age at initiation increased with increasing risk severity across the behaviors, contributing to evidence of a trajectory from opioid pill misuse to opioid injection. Discussion: Increasing number of childhood traumas was associated with increased odds of earlier initiation of multiple opioid misuse behaviors. In light of prior research linking earlier initiation of substance use with increased substance use severity, present findings suggest the importance of ACEs as individual-level determinants of increased opioid use severity. Efforts to prevent onset and escalation of opioid use among at-risk youth may benefit from trauma prevention programs and trauma-focused screening and treatment, as well as increased attention to ameliorating upstream socio-structural drivers of childhood trauma.
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spelling pubmed-81589342021-05-28 Adverse Childhood Experiences Predict Early Initiation of Opioid Use Behaviors Guarino, Honoria Mateu-Gelabert, Pedro Quinn, Kelly Sirikantraporn, Skultip Ruggles, Kelly V. Syckes, Cassandra Goodbody, Elizabeth Jessell, Lauren Friedman, Samuel R. Front Sociol Sociology Introduction: Although a substantial body of research documents a relationship between traumatic stress in childhood and the initiation of substance use later in the life course, only limited research has examined potential linkages between adverse childhood experiences (ACEs) and the initiation of non-medical prescription opioid use and other opioid use behaviors. The present study contributes to this growing body of work by investigating the association of childhood trauma with early initiation of a series of opioid use behaviors. Methods: New York City young adults (n = 539) ages 18–29 who reported non-medical use of prescription opioids or heroin use in the past 30 days were recruited using Respondent-Driven Sampling in 2014–16. Ten ACEs were assessed via self-report with the ACE Questionnaire. Associations between number of ACEs and self-reported ages of initiating seven opioid use behaviors (e.g., non-medical prescription opioid use, heroin use, heroin injection) were estimated with multivariable logistic regression. Results: Eighty nine percent of participants reported at least one ACE, and 46% reported four or more ACEs, a well-supported threshold indicating elevated risk for negative health consequences. Every increase of one trauma was associated with a 12–23% increase in odds of early initiation across the seven opioid use behaviors. Findings also document that the mean age at initiation increased with increasing risk severity across the behaviors, contributing to evidence of a trajectory from opioid pill misuse to opioid injection. Discussion: Increasing number of childhood traumas was associated with increased odds of earlier initiation of multiple opioid misuse behaviors. In light of prior research linking earlier initiation of substance use with increased substance use severity, present findings suggest the importance of ACEs as individual-level determinants of increased opioid use severity. Efforts to prevent onset and escalation of opioid use among at-risk youth may benefit from trauma prevention programs and trauma-focused screening and treatment, as well as increased attention to ameliorating upstream socio-structural drivers of childhood trauma. Frontiers Media S.A. 2021-05-13 /pmc/articles/PMC8158934/ /pubmed/34055961 http://dx.doi.org/10.3389/fsoc.2021.620395 Text en Copyright © 2021 Guarino, Mateu-Gelabert, Quinn, Sirikantraporn, Ruggles, Syckes, Goodbody, Jessell and Friedman. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Sociology
Guarino, Honoria
Mateu-Gelabert, Pedro
Quinn, Kelly
Sirikantraporn, Skultip
Ruggles, Kelly V.
Syckes, Cassandra
Goodbody, Elizabeth
Jessell, Lauren
Friedman, Samuel R.
Adverse Childhood Experiences Predict Early Initiation of Opioid Use Behaviors
title Adverse Childhood Experiences Predict Early Initiation of Opioid Use Behaviors
title_full Adverse Childhood Experiences Predict Early Initiation of Opioid Use Behaviors
title_fullStr Adverse Childhood Experiences Predict Early Initiation of Opioid Use Behaviors
title_full_unstemmed Adverse Childhood Experiences Predict Early Initiation of Opioid Use Behaviors
title_short Adverse Childhood Experiences Predict Early Initiation of Opioid Use Behaviors
title_sort adverse childhood experiences predict early initiation of opioid use behaviors
topic Sociology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158934/
https://www.ncbi.nlm.nih.gov/pubmed/34055961
http://dx.doi.org/10.3389/fsoc.2021.620395
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