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Correlation between neonatal hyperbilirubinemia and vitamin D levels: A meta-analysis

OBJECTIVE: Hyperbilirubinemia is a common disease in the neonatal period, and hyperbilirubinemia may cause brain damage. Therefore, prevention and diagnosis and management of hyperbilirubinemia is very important, and vitamin D may affect bilirubin levels. To evaluate the relationship between neonata...

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Autores principales: Huang, Jiayu, Zhao, Qian, Li, Jiao, Meng, Jinfeng, Li, Shangbin, Yan, Weichen, Wang, Jie, Ren, Changjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158937/
https://www.ncbi.nlm.nih.gov/pubmed/34043645
http://dx.doi.org/10.1371/journal.pone.0251584
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author Huang, Jiayu
Zhao, Qian
Li, Jiao
Meng, Jinfeng
Li, Shangbin
Yan, Weichen
Wang, Jie
Ren, Changjun
author_facet Huang, Jiayu
Zhao, Qian
Li, Jiao
Meng, Jinfeng
Li, Shangbin
Yan, Weichen
Wang, Jie
Ren, Changjun
author_sort Huang, Jiayu
collection PubMed
description OBJECTIVE: Hyperbilirubinemia is a common disease in the neonatal period, and hyperbilirubinemia may cause brain damage. Therefore, prevention and diagnosis and management of hyperbilirubinemia is very important, and vitamin D may affect bilirubin levels. To evaluate the relationship between neonatal hyperbilirubinemia and vitamin D levels. METHOD: The China National Knowledge Infrastructure, VIP, Wanfang, Chinese Biology Medicine Disc, PubMed, Web of Science, Cochrane Library, and Embase databases as well as clinical trial registries in China and the United States were searched for relevant studies from inception to September 2020 without restrictions on language, population, or year. The studies was screened by two reviewers independently, the data were extracted, and the risk of bias of the included studies was evaluated using the NOS. A meta-analysis was conducted on the included studies using Stata11 software. RESULTS: Six case-control studies were included, and the methodological quality of the studies was high (grade A). The studies included 690 newborns; more than 409 were diagnosed with hyperbilirubinemia. The means and standard deviations were calculated. Meta-analysis results showed that neonatal vitamin D levels were 7.1 ng/ml lower among infants with hyperbilirubinemia than among healthy newborn levels (z = 6.95, 95% CI 9.10 ~ 5.09, P < 0.05). Subgroup analysis was conducted based on whether the bilirubin levels were concentrated in the 15 to 20 mg/dl range. Vitamin D level of infants with hyperbilirubinemia (the bilirubin levels were concentrated in the 15 to 20 mg/dl range) was 9.52 ng/ml (Z = 15.55, 95% CI-10.72~-8.32, P<0.05) lower than that of healthy infants. The bilirubin levels in four cases were not concentrated in the 15–20 mg/dl range. The results showed that the vitamin D level of hyperbilirubinemia (The bilirubin levels were not concentrated in the 15–20 mg/dl range) neonates were 5.35 ng/ml lower than that of healthy neonates (Z = 6.43, 95% CI-6.98~-3.72, P<0.05). CONCLUSION: Vitamin D levels were observed to be lower in neonates with hyperbilirubinemia as compared to term neonates without hyperbilirubinemia in this study. This can possibly suggest that neonates with lower vitamin D levels are at higher risk for developing hyperbilirubinemia.
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spelling pubmed-81589372021-06-09 Correlation between neonatal hyperbilirubinemia and vitamin D levels: A meta-analysis Huang, Jiayu Zhao, Qian Li, Jiao Meng, Jinfeng Li, Shangbin Yan, Weichen Wang, Jie Ren, Changjun PLoS One Research Article OBJECTIVE: Hyperbilirubinemia is a common disease in the neonatal period, and hyperbilirubinemia may cause brain damage. Therefore, prevention and diagnosis and management of hyperbilirubinemia is very important, and vitamin D may affect bilirubin levels. To evaluate the relationship between neonatal hyperbilirubinemia and vitamin D levels. METHOD: The China National Knowledge Infrastructure, VIP, Wanfang, Chinese Biology Medicine Disc, PubMed, Web of Science, Cochrane Library, and Embase databases as well as clinical trial registries in China and the United States were searched for relevant studies from inception to September 2020 without restrictions on language, population, or year. The studies was screened by two reviewers independently, the data were extracted, and the risk of bias of the included studies was evaluated using the NOS. A meta-analysis was conducted on the included studies using Stata11 software. RESULTS: Six case-control studies were included, and the methodological quality of the studies was high (grade A). The studies included 690 newborns; more than 409 were diagnosed with hyperbilirubinemia. The means and standard deviations were calculated. Meta-analysis results showed that neonatal vitamin D levels were 7.1 ng/ml lower among infants with hyperbilirubinemia than among healthy newborn levels (z = 6.95, 95% CI 9.10 ~ 5.09, P < 0.05). Subgroup analysis was conducted based on whether the bilirubin levels were concentrated in the 15 to 20 mg/dl range. Vitamin D level of infants with hyperbilirubinemia (the bilirubin levels were concentrated in the 15 to 20 mg/dl range) was 9.52 ng/ml (Z = 15.55, 95% CI-10.72~-8.32, P<0.05) lower than that of healthy infants. The bilirubin levels in four cases were not concentrated in the 15–20 mg/dl range. The results showed that the vitamin D level of hyperbilirubinemia (The bilirubin levels were not concentrated in the 15–20 mg/dl range) neonates were 5.35 ng/ml lower than that of healthy neonates (Z = 6.43, 95% CI-6.98~-3.72, P<0.05). CONCLUSION: Vitamin D levels were observed to be lower in neonates with hyperbilirubinemia as compared to term neonates without hyperbilirubinemia in this study. This can possibly suggest that neonates with lower vitamin D levels are at higher risk for developing hyperbilirubinemia. Public Library of Science 2021-05-27 /pmc/articles/PMC8158937/ /pubmed/34043645 http://dx.doi.org/10.1371/journal.pone.0251584 Text en © 2021 Huang et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Huang, Jiayu
Zhao, Qian
Li, Jiao
Meng, Jinfeng
Li, Shangbin
Yan, Weichen
Wang, Jie
Ren, Changjun
Correlation between neonatal hyperbilirubinemia and vitamin D levels: A meta-analysis
title Correlation between neonatal hyperbilirubinemia and vitamin D levels: A meta-analysis
title_full Correlation between neonatal hyperbilirubinemia and vitamin D levels: A meta-analysis
title_fullStr Correlation between neonatal hyperbilirubinemia and vitamin D levels: A meta-analysis
title_full_unstemmed Correlation between neonatal hyperbilirubinemia and vitamin D levels: A meta-analysis
title_short Correlation between neonatal hyperbilirubinemia and vitamin D levels: A meta-analysis
title_sort correlation between neonatal hyperbilirubinemia and vitamin d levels: a meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158937/
https://www.ncbi.nlm.nih.gov/pubmed/34043645
http://dx.doi.org/10.1371/journal.pone.0251584
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