High titers and low fucosylation of early human anti-SARS-CoV-2 IgG promote inflammation by alveolar macrophages

Patients diagnosed with coronavirus disease 2019 (COVID-19) become critically ill primarily around the time of activation of the adaptive immune response. Here, we provide evidence that antibodies play a role in the worsening of disease at the time of seroconversion. We show that early phase severe...

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Detalles Bibliográficos
Autores principales: Hoepel, Willianne, Chen, Hung-Jen, Geyer, Chiara E., Allahverdiyeva, Sona, Manz, Xue D., de Taeye, Steven W., Aman, Jurjan, Mes, Lynn, Steenhuis, Maurice, Griffith, Guillermo R., Bonta, Peter I., Brouwer, Philip J.M., Caniels, Tom G., van der Straten, Karlijn, Golebski, Korneliusz, Jonkers, René E., Larsen, Mads D., Linty, Federica, Nouta, Jan, van Roomen, Cindy P.A.A., van Baarle, Frank E.H.P., van Drunen, Cornelis M., Wolbink, Gertjan, Vlaar, Alexander P.J., de Bree, Godelieve J., Sanders, Rogier W., Willemsen, Lisa, Neele, Annette E., van de Beek, Diederik, Rispens, Theo, Wuhrer, Manfred, Bogaard, Harm Jan, van Gils, Marit J., Vidarsson, Gestur, de Winther, Menno, den Dunnen, Jeroen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158960/
https://www.ncbi.nlm.nih.gov/pubmed/33979301
http://dx.doi.org/10.1126/scitranslmed.abf8654

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