Cargando…

Causal Association between Periodontitis and Parkinson’s Disease: A Bidirectional Mendelian Randomization Study

The latest evidence revealed a possible association between periodontitis and Parkinson’s disease (PD). We explored the causal relationship of this bidirectional association through two-sample Mendelian randomization (MR) in European ancestry populations. To this end, we used openly accessible data...

Descripción completa

Detalles Bibliográficos
Autores principales: Botelho, João, Machado, Vanessa, Mendes, José João, Mascarenhas, Paulo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159074/
https://www.ncbi.nlm.nih.gov/pubmed/34069479
http://dx.doi.org/10.3390/genes12050772
_version_ 1783700003438460928
author Botelho, João
Machado, Vanessa
Mendes, José João
Mascarenhas, Paulo
author_facet Botelho, João
Machado, Vanessa
Mendes, José João
Mascarenhas, Paulo
author_sort Botelho, João
collection PubMed
description The latest evidence revealed a possible association between periodontitis and Parkinson’s disease (PD). We explored the causal relationship of this bidirectional association through two-sample Mendelian randomization (MR) in European ancestry populations. To this end, we used openly accessible data of genome-wide association studies (GWAS) on periodontitis and PD. As instrumental variables for periodontitis, seventeen single-nucleotide polymorphisms (SNPs) from a GWAS of periodontitis (1817 periodontitis cases vs. 2215 controls) and eight non-overlapping SNPs of periodontitis from an additional GWAS for validation purposes. Instrumental variables to explore for the reverse causation included forty-five SNPs from a GWAS of PD (20,184 cases and 397,324 controls). Multiple approaches of MR were carried-out. There was no evidence of genetic liability of periodontitis being associated with a higher risk of PD (B = −0.0003, Standard Error [SE] 0.0003, p = 0.26). The eight independent SNPs (B = −0.0000, SE 0.0001, p = 0.99) validated this outcome. We also found no association of genetically primed PD towards periodontitis (B = −0.0001, SE 0.0001, p = 0.19). These MR study findings do not support a bidirectional causal genetic liability between periodontitis and PD. Further GWAS studies are needed to confirm the consistency of these results.
format Online
Article
Text
id pubmed-8159074
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-81590742021-05-28 Causal Association between Periodontitis and Parkinson’s Disease: A Bidirectional Mendelian Randomization Study Botelho, João Machado, Vanessa Mendes, José João Mascarenhas, Paulo Genes (Basel) Article The latest evidence revealed a possible association between periodontitis and Parkinson’s disease (PD). We explored the causal relationship of this bidirectional association through two-sample Mendelian randomization (MR) in European ancestry populations. To this end, we used openly accessible data of genome-wide association studies (GWAS) on periodontitis and PD. As instrumental variables for periodontitis, seventeen single-nucleotide polymorphisms (SNPs) from a GWAS of periodontitis (1817 periodontitis cases vs. 2215 controls) and eight non-overlapping SNPs of periodontitis from an additional GWAS for validation purposes. Instrumental variables to explore for the reverse causation included forty-five SNPs from a GWAS of PD (20,184 cases and 397,324 controls). Multiple approaches of MR were carried-out. There was no evidence of genetic liability of periodontitis being associated with a higher risk of PD (B = −0.0003, Standard Error [SE] 0.0003, p = 0.26). The eight independent SNPs (B = −0.0000, SE 0.0001, p = 0.99) validated this outcome. We also found no association of genetically primed PD towards periodontitis (B = −0.0001, SE 0.0001, p = 0.19). These MR study findings do not support a bidirectional causal genetic liability between periodontitis and PD. Further GWAS studies are needed to confirm the consistency of these results. MDPI 2021-05-19 /pmc/articles/PMC8159074/ /pubmed/34069479 http://dx.doi.org/10.3390/genes12050772 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Botelho, João
Machado, Vanessa
Mendes, José João
Mascarenhas, Paulo
Causal Association between Periodontitis and Parkinson’s Disease: A Bidirectional Mendelian Randomization Study
title Causal Association between Periodontitis and Parkinson’s Disease: A Bidirectional Mendelian Randomization Study
title_full Causal Association between Periodontitis and Parkinson’s Disease: A Bidirectional Mendelian Randomization Study
title_fullStr Causal Association between Periodontitis and Parkinson’s Disease: A Bidirectional Mendelian Randomization Study
title_full_unstemmed Causal Association between Periodontitis and Parkinson’s Disease: A Bidirectional Mendelian Randomization Study
title_short Causal Association between Periodontitis and Parkinson’s Disease: A Bidirectional Mendelian Randomization Study
title_sort causal association between periodontitis and parkinson’s disease: a bidirectional mendelian randomization study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159074/
https://www.ncbi.nlm.nih.gov/pubmed/34069479
http://dx.doi.org/10.3390/genes12050772
work_keys_str_mv AT botelhojoao causalassociationbetweenperiodontitisandparkinsonsdiseaseabidirectionalmendelianrandomizationstudy
AT machadovanessa causalassociationbetweenperiodontitisandparkinsonsdiseaseabidirectionalmendelianrandomizationstudy
AT mendesjosejoao causalassociationbetweenperiodontitisandparkinsonsdiseaseabidirectionalmendelianrandomizationstudy
AT mascarenhaspaulo causalassociationbetweenperiodontitisandparkinsonsdiseaseabidirectionalmendelianrandomizationstudy