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Causal Association between Periodontitis and Parkinson’s Disease: A Bidirectional Mendelian Randomization Study
The latest evidence revealed a possible association between periodontitis and Parkinson’s disease (PD). We explored the causal relationship of this bidirectional association through two-sample Mendelian randomization (MR) in European ancestry populations. To this end, we used openly accessible data...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159074/ https://www.ncbi.nlm.nih.gov/pubmed/34069479 http://dx.doi.org/10.3390/genes12050772 |
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author | Botelho, João Machado, Vanessa Mendes, José João Mascarenhas, Paulo |
author_facet | Botelho, João Machado, Vanessa Mendes, José João Mascarenhas, Paulo |
author_sort | Botelho, João |
collection | PubMed |
description | The latest evidence revealed a possible association between periodontitis and Parkinson’s disease (PD). We explored the causal relationship of this bidirectional association through two-sample Mendelian randomization (MR) in European ancestry populations. To this end, we used openly accessible data of genome-wide association studies (GWAS) on periodontitis and PD. As instrumental variables for periodontitis, seventeen single-nucleotide polymorphisms (SNPs) from a GWAS of periodontitis (1817 periodontitis cases vs. 2215 controls) and eight non-overlapping SNPs of periodontitis from an additional GWAS for validation purposes. Instrumental variables to explore for the reverse causation included forty-five SNPs from a GWAS of PD (20,184 cases and 397,324 controls). Multiple approaches of MR were carried-out. There was no evidence of genetic liability of periodontitis being associated with a higher risk of PD (B = −0.0003, Standard Error [SE] 0.0003, p = 0.26). The eight independent SNPs (B = −0.0000, SE 0.0001, p = 0.99) validated this outcome. We also found no association of genetically primed PD towards periodontitis (B = −0.0001, SE 0.0001, p = 0.19). These MR study findings do not support a bidirectional causal genetic liability between periodontitis and PD. Further GWAS studies are needed to confirm the consistency of these results. |
format | Online Article Text |
id | pubmed-8159074 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81590742021-05-28 Causal Association between Periodontitis and Parkinson’s Disease: A Bidirectional Mendelian Randomization Study Botelho, João Machado, Vanessa Mendes, José João Mascarenhas, Paulo Genes (Basel) Article The latest evidence revealed a possible association between periodontitis and Parkinson’s disease (PD). We explored the causal relationship of this bidirectional association through two-sample Mendelian randomization (MR) in European ancestry populations. To this end, we used openly accessible data of genome-wide association studies (GWAS) on periodontitis and PD. As instrumental variables for periodontitis, seventeen single-nucleotide polymorphisms (SNPs) from a GWAS of periodontitis (1817 periodontitis cases vs. 2215 controls) and eight non-overlapping SNPs of periodontitis from an additional GWAS for validation purposes. Instrumental variables to explore for the reverse causation included forty-five SNPs from a GWAS of PD (20,184 cases and 397,324 controls). Multiple approaches of MR were carried-out. There was no evidence of genetic liability of periodontitis being associated with a higher risk of PD (B = −0.0003, Standard Error [SE] 0.0003, p = 0.26). The eight independent SNPs (B = −0.0000, SE 0.0001, p = 0.99) validated this outcome. We also found no association of genetically primed PD towards periodontitis (B = −0.0001, SE 0.0001, p = 0.19). These MR study findings do not support a bidirectional causal genetic liability between periodontitis and PD. Further GWAS studies are needed to confirm the consistency of these results. MDPI 2021-05-19 /pmc/articles/PMC8159074/ /pubmed/34069479 http://dx.doi.org/10.3390/genes12050772 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Botelho, João Machado, Vanessa Mendes, José João Mascarenhas, Paulo Causal Association between Periodontitis and Parkinson’s Disease: A Bidirectional Mendelian Randomization Study |
title | Causal Association between Periodontitis and Parkinson’s Disease: A Bidirectional Mendelian Randomization Study |
title_full | Causal Association between Periodontitis and Parkinson’s Disease: A Bidirectional Mendelian Randomization Study |
title_fullStr | Causal Association between Periodontitis and Parkinson’s Disease: A Bidirectional Mendelian Randomization Study |
title_full_unstemmed | Causal Association between Periodontitis and Parkinson’s Disease: A Bidirectional Mendelian Randomization Study |
title_short | Causal Association between Periodontitis and Parkinson’s Disease: A Bidirectional Mendelian Randomization Study |
title_sort | causal association between periodontitis and parkinson’s disease: a bidirectional mendelian randomization study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159074/ https://www.ncbi.nlm.nih.gov/pubmed/34069479 http://dx.doi.org/10.3390/genes12050772 |
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