Improvement of Oral Bioavailability of Pyrazolo-Pyridone Inhibitors of the Interaction of DCN1/2 and UBE2M

[Image: see text] The cullin-RING ubiquitin ligases (CRLs) are ubiquitin E3 enzymes that play a key role in controlling proteasomal degradation and are activated by neddylation. We previously reported inhibitors that target CRL activation by disrupting the interaction of defective in cullin neddylat...

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Detalles Bibliográficos
Autores principales: Kim, Ho Shin, Hammill, Jared T., Scott, Daniel C., Chen, Yizhe, Rice, Amy L., Pistel, William, Singh, Bhuvanesh, Schulman, Brenda A., Guy, R. Kiplin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159160/
https://www.ncbi.nlm.nih.gov/pubmed/33945681
http://dx.doi.org/10.1021/acs.jmedchem.1c00035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159160/
https://www.ncbi.nlm.nih.gov/pubmed/33945681
http://dx.doi.org/10.1021/acs.jmedchem.1c00035

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