Metal-free electrochemical fluorodecarboxylation of aryloxyacetic acids to fluoromethyl aryl ethers

Electrochemical decarboxylation of aryloxyacetic acids followed by fluorination provides easy access to fluoromethyl aryl ethers. This electrochemical fluorodecarboxylation offers a sustainable approach with electric current as traceless oxidant. Using Et(3)N·5HF as fluoride source and as supporting...

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Autores principales: Berger, Michael, Herszman, John D., Kurimoto, Yuji, de Kruijff, Goswinus H. M., Schüll, Aaron, Ruf, Sven, Waldvogel, Siegfried R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159297/
https://www.ncbi.nlm.nih.gov/pubmed/34094098
http://dx.doi.org/10.1039/d0sc02417a
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author Berger, Michael
Herszman, John D.
Kurimoto, Yuji
de Kruijff, Goswinus H. M.
Schüll, Aaron
Ruf, Sven
Waldvogel, Siegfried R.
author_facet Berger, Michael
Herszman, John D.
Kurimoto, Yuji
de Kruijff, Goswinus H. M.
Schüll, Aaron
Ruf, Sven
Waldvogel, Siegfried R.
author_sort Berger, Michael
collection PubMed
description Electrochemical decarboxylation of aryloxyacetic acids followed by fluorination provides easy access to fluoromethyl aryl ethers. This electrochemical fluorodecarboxylation offers a sustainable approach with electric current as traceless oxidant. Using Et(3)N·5HF as fluoride source and as supporting electrolyte, this simple electrosynthesis affords various fluoromethoxyarenes in yields up to 85%.
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spelling pubmed-81592972021-06-04 Metal-free electrochemical fluorodecarboxylation of aryloxyacetic acids to fluoromethyl aryl ethers Berger, Michael Herszman, John D. Kurimoto, Yuji de Kruijff, Goswinus H. M. Schüll, Aaron Ruf, Sven Waldvogel, Siegfried R. Chem Sci Chemistry Electrochemical decarboxylation of aryloxyacetic acids followed by fluorination provides easy access to fluoromethyl aryl ethers. This electrochemical fluorodecarboxylation offers a sustainable approach with electric current as traceless oxidant. Using Et(3)N·5HF as fluoride source and as supporting electrolyte, this simple electrosynthesis affords various fluoromethoxyarenes in yields up to 85%. The Royal Society of Chemistry 2020-06-01 /pmc/articles/PMC8159297/ /pubmed/34094098 http://dx.doi.org/10.1039/d0sc02417a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Berger, Michael
Herszman, John D.
Kurimoto, Yuji
de Kruijff, Goswinus H. M.
Schüll, Aaron
Ruf, Sven
Waldvogel, Siegfried R.
Metal-free electrochemical fluorodecarboxylation of aryloxyacetic acids to fluoromethyl aryl ethers
title Metal-free electrochemical fluorodecarboxylation of aryloxyacetic acids to fluoromethyl aryl ethers
title_full Metal-free electrochemical fluorodecarboxylation of aryloxyacetic acids to fluoromethyl aryl ethers
title_fullStr Metal-free electrochemical fluorodecarboxylation of aryloxyacetic acids to fluoromethyl aryl ethers
title_full_unstemmed Metal-free electrochemical fluorodecarboxylation of aryloxyacetic acids to fluoromethyl aryl ethers
title_short Metal-free electrochemical fluorodecarboxylation of aryloxyacetic acids to fluoromethyl aryl ethers
title_sort metal-free electrochemical fluorodecarboxylation of aryloxyacetic acids to fluoromethyl aryl ethers
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159297/
https://www.ncbi.nlm.nih.gov/pubmed/34094098
http://dx.doi.org/10.1039/d0sc02417a
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