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Differentiating Aβ40 and Aβ42 in amyloid plaques with a small molecule fluorescence probe

Differentiating amyloid beta (Aβ) subspecies Aβ40 and Aβ42 has long been considered an impossible mission with small-molecule probes. In this report, based on recently published structures of Aβ fibrils, we designed iminocoumarin–thiazole (ICT) fluorescence probes to differentiate Aβ40 and Aβ42, amo...

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Detalles Bibliográficos
Autores principales: Yang, Jing, Zhu, Biyue, Yin, Wei, Han, Zhihao, Zheng, Chao, Wang, Peng, Ran, Chongzhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159352/
https://www.ncbi.nlm.nih.gov/pubmed/34122980
http://dx.doi.org/10.1039/d0sc02060e

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