Testing the limits of radical-anionic CH-amination: a 10-million-fold decrease in basicity opens a new path to hydroxyisoindolines via a mixed C–N/C–O-forming cascade

An intramolecular C(sp(3))–H amidation proceeds in the presence of t-BuOK, molecular oxygen, and DMF. This transformation is initiated by the deprotonation of an acidic N–H bond and selective radical activation of a benzylic C–H bond towards hydrogen atom transfer (HAT). Cyclization of this radical–...

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Detalles Bibliográficos
Autores principales: Elliott, Quintin, dos Passos Gomes, Gabriel, Evoniuk, Christopher J., Alabugin, Igor V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159354/
https://www.ncbi.nlm.nih.gov/pubmed/34094120
http://dx.doi.org/10.1039/c9sc06511c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159354/
https://www.ncbi.nlm.nih.gov/pubmed/34094120
http://dx.doi.org/10.1039/c9sc06511c

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