“CLipP”ing on lipids to generate antibacterial lipopeptides

We herein report the synthesis and biological and computational evaluation of 12 linear analogues of the cyclic lipopeptide battacin, enabled by Cysteine Lipidation on a Peptide or Amino Acid (CLipPA) technology. Several of the novel “CLipP”ed lipopeptides exhibited low micromolar MICs and MBCs agai...

Descripción completa

Detalles Bibliográficos
Autores principales: Yim, Victor, Kavianinia, Iman, Knottenbelt, Melanie K., Ferguson, Scott A., Cook, Gregory M., Swift, Simon, Chakraborty, Aparajita, Allison, Jane R., Cameron, Alan J., Harris, Paul W. R., Brimble, Margaret A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159387/
https://www.ncbi.nlm.nih.gov/pubmed/34094080
http://dx.doi.org/10.1039/d0sc01814g
_version_ 1783700074912546816
author Yim, Victor
Kavianinia, Iman
Knottenbelt, Melanie K.
Ferguson, Scott A.
Cook, Gregory M.
Swift, Simon
Chakraborty, Aparajita
Allison, Jane R.
Cameron, Alan J.
Harris, Paul W. R.
Brimble, Margaret A.
author_facet Yim, Victor
Kavianinia, Iman
Knottenbelt, Melanie K.
Ferguson, Scott A.
Cook, Gregory M.
Swift, Simon
Chakraborty, Aparajita
Allison, Jane R.
Cameron, Alan J.
Harris, Paul W. R.
Brimble, Margaret A.
author_sort Yim, Victor
collection PubMed
description We herein report the synthesis and biological and computational evaluation of 12 linear analogues of the cyclic lipopeptide battacin, enabled by Cysteine Lipidation on a Peptide or Amino Acid (CLipPA) technology. Several of the novel “CLipP”ed lipopeptides exhibited low micromolar MICs and MBCs against both Gram-negative and Gram-positive bacteria. The mechanism of action was then simulated with the MIC data using computational methods.
format Online
Article
Text
id pubmed-8159387
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher The Royal Society of Chemistry
record_format MEDLINE/PubMed
spelling pubmed-81593872021-06-04 “CLipP”ing on lipids to generate antibacterial lipopeptides Yim, Victor Kavianinia, Iman Knottenbelt, Melanie K. Ferguson, Scott A. Cook, Gregory M. Swift, Simon Chakraborty, Aparajita Allison, Jane R. Cameron, Alan J. Harris, Paul W. R. Brimble, Margaret A. Chem Sci Chemistry We herein report the synthesis and biological and computational evaluation of 12 linear analogues of the cyclic lipopeptide battacin, enabled by Cysteine Lipidation on a Peptide or Amino Acid (CLipPA) technology. Several of the novel “CLipP”ed lipopeptides exhibited low micromolar MICs and MBCs against both Gram-negative and Gram-positive bacteria. The mechanism of action was then simulated with the MIC data using computational methods. The Royal Society of Chemistry 2020-05-20 /pmc/articles/PMC8159387/ /pubmed/34094080 http://dx.doi.org/10.1039/d0sc01814g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Yim, Victor
Kavianinia, Iman
Knottenbelt, Melanie K.
Ferguson, Scott A.
Cook, Gregory M.
Swift, Simon
Chakraborty, Aparajita
Allison, Jane R.
Cameron, Alan J.
Harris, Paul W. R.
Brimble, Margaret A.
“CLipP”ing on lipids to generate antibacterial lipopeptides
title “CLipP”ing on lipids to generate antibacterial lipopeptides
title_full “CLipP”ing on lipids to generate antibacterial lipopeptides
title_fullStr “CLipP”ing on lipids to generate antibacterial lipopeptides
title_full_unstemmed “CLipP”ing on lipids to generate antibacterial lipopeptides
title_short “CLipP”ing on lipids to generate antibacterial lipopeptides
title_sort “clipp”ing on lipids to generate antibacterial lipopeptides
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159387/
https://www.ncbi.nlm.nih.gov/pubmed/34094080
http://dx.doi.org/10.1039/d0sc01814g
work_keys_str_mv AT yimvictor clippingonlipidstogenerateantibacteriallipopeptides
AT kavianiniaiman clippingonlipidstogenerateantibacteriallipopeptides
AT knottenbeltmelaniek clippingonlipidstogenerateantibacteriallipopeptides
AT fergusonscotta clippingonlipidstogenerateantibacteriallipopeptides
AT cookgregorym clippingonlipidstogenerateantibacteriallipopeptides
AT swiftsimon clippingonlipidstogenerateantibacteriallipopeptides
AT chakrabortyaparajita clippingonlipidstogenerateantibacteriallipopeptides
AT allisonjaner clippingonlipidstogenerateantibacteriallipopeptides
AT cameronalanj clippingonlipidstogenerateantibacteriallipopeptides
AT harrispaulwr clippingonlipidstogenerateantibacteriallipopeptides
AT brimblemargareta clippingonlipidstogenerateantibacteriallipopeptides

Ejemplares similares