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Palladium-catalyzed synthesis of β-hydroxy compounds via a strained 6,4-palladacycle from directed C–H activation of anilines and C–O insertion of epoxides

A palladium-catalyzed C–H activation of acetylated anilines (acetanilides, 1,1-dimethyl-3-phenylurea, 1-phenylpyrrolidin-2-one, and 1-(indolin-1-yl)ethan-1-one) with epoxides using O-coordinating directing groups was accomplished. This C–H alkylation reaction proceeds via formation of a previously u...

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Detalles Bibliográficos
Autores principales: Thombal, Raju S., Feoktistova, Taisiia, González-Montiel, Gisela A., Cheong, Paul H.-Y., Lee, Yong Rok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159402/
https://www.ncbi.nlm.nih.gov/pubmed/34123012
http://dx.doi.org/10.1039/d0sc01462a