Unusually high α-proton acidity of prolyl residues in cyclic peptides

The acidity of the α-proton in peptides has an essential role in numerous biochemical reactions and underpins their stereochemical integrity, which is critical to their biological function. We report a detailed kinetic and computational study of the acidity of the α-proton in two cyclic peptide syst...

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Detalles Bibliográficos
Autores principales: Maguire, Oliver R., Taylor, Bethany, Higgins, Eleanor M., Rees, Matthew, Cobb, Steven L., Simpkins, Nigel S., Hayes, Christopher J., O'Donoghue, AnnMarie C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159430/
https://www.ncbi.nlm.nih.gov/pubmed/34094148
http://dx.doi.org/10.1039/d0sc02508a

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