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Macroscopic on-site evaluation (MOSE) of specimens from solid lesions acquired during EUS-FNB: multicenter study and comparison between needle gauges

Background and study aims  The standard method for obtaining samples during endoscopic ultrasonography (EUS) is fine-needle aspiration (FNA), the accuracy of which can be affected by the presence of a cytopathologist in endoscopy room (rapid on-site evaluation [ROSE]). With the introduction of fine-...

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Autores principales: Mangiavillano, Benedetto, Frazzoni, Leonardo, Togliani, Thomas, Fabbri, Carlo, Tarantino, Ilaria, De Luca, Luca, Staiano, Teresa, Binda, Cecilia, Signoretti, Marianna, Eusebi, Leonardo H., Auriemma, Francesco, Lamonaca, Laura, Paduano, Danilo, Di Leo, Milena, Carrara, Silvia, Fuccio, Lorenzo, Repici, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159577/
https://www.ncbi.nlm.nih.gov/pubmed/34079874
http://dx.doi.org/10.1055/a-1395-7129
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author Mangiavillano, Benedetto
Frazzoni, Leonardo
Togliani, Thomas
Fabbri, Carlo
Tarantino, Ilaria
De Luca, Luca
Staiano, Teresa
Binda, Cecilia
Signoretti, Marianna
Eusebi, Leonardo H.
Auriemma, Francesco
Lamonaca, Laura
Paduano, Danilo
Di Leo, Milena
Carrara, Silvia
Fuccio, Lorenzo
Repici, Alessandro
author_facet Mangiavillano, Benedetto
Frazzoni, Leonardo
Togliani, Thomas
Fabbri, Carlo
Tarantino, Ilaria
De Luca, Luca
Staiano, Teresa
Binda, Cecilia
Signoretti, Marianna
Eusebi, Leonardo H.
Auriemma, Francesco
Lamonaca, Laura
Paduano, Danilo
Di Leo, Milena
Carrara, Silvia
Fuccio, Lorenzo
Repici, Alessandro
author_sort Mangiavillano, Benedetto
collection PubMed
description Background and study aims  The standard method for obtaining samples during endoscopic ultrasonography (EUS) is fine-needle aspiration (FNA), the accuracy of which can be affected by the presence of a cytopathologist in endoscopy room (rapid on-site evaluation [ROSE]). With the introduction of fine-needle biopsy (FNB), macroscopic on-site evaluation (MOSE) of a acquired specimen has been proposed. Only a few studies have evaluated the role of MOSE and in all except one, a 19G needle was used. Our primary aim was to evaluate the diagnostic yield and accuracy of MOSE with different needle sizes and the secondary aim was to identify factors influencing the yield of MOSE. Patients and methods  Data from patients who underwent EUS-FNB for solid lesions, with MOSE evaluation of the specimen, were collected in six endoscopic referral centers. Results  A total of 378 patients (145 F and 233 M) were enrolled. Needles sizes used during the procedures were 20G (42 %), 22G (45 %), and 25G (13 %). The median number of needle passes was two (IQR 2–3). The overall diagnostic yield of MOSE was of 90 % (confidence interval [CI] 86 %–92 %). On multivariable logistic regression analysis, variables independently associated with the diagnostic yield of MOSE were a larger needle diameter (20G vs. 25G, OR 11.64, 95 %CI 3.5–38.71; 22G vs. 25G, OR 6.20, 95 %CI 2.41–15.90) and three of more needle passes (OR 3.39, 95 %CI 1.38–8.31). Conclusions  MOSE showed high diagnostic yield and accuracy. Its yield was further increased if performed with a large size FNB needles and more than two passes.
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spelling pubmed-81595772021-06-01 Macroscopic on-site evaluation (MOSE) of specimens from solid lesions acquired during EUS-FNB: multicenter study and comparison between needle gauges Mangiavillano, Benedetto Frazzoni, Leonardo Togliani, Thomas Fabbri, Carlo Tarantino, Ilaria De Luca, Luca Staiano, Teresa Binda, Cecilia Signoretti, Marianna Eusebi, Leonardo H. Auriemma, Francesco Lamonaca, Laura Paduano, Danilo Di Leo, Milena Carrara, Silvia Fuccio, Lorenzo Repici, Alessandro Endosc Int Open Background and study aims  The standard method for obtaining samples during endoscopic ultrasonography (EUS) is fine-needle aspiration (FNA), the accuracy of which can be affected by the presence of a cytopathologist in endoscopy room (rapid on-site evaluation [ROSE]). With the introduction of fine-needle biopsy (FNB), macroscopic on-site evaluation (MOSE) of a acquired specimen has been proposed. Only a few studies have evaluated the role of MOSE and in all except one, a 19G needle was used. Our primary aim was to evaluate the diagnostic yield and accuracy of MOSE with different needle sizes and the secondary aim was to identify factors influencing the yield of MOSE. Patients and methods  Data from patients who underwent EUS-FNB for solid lesions, with MOSE evaluation of the specimen, were collected in six endoscopic referral centers. Results  A total of 378 patients (145 F and 233 M) were enrolled. Needles sizes used during the procedures were 20G (42 %), 22G (45 %), and 25G (13 %). The median number of needle passes was two (IQR 2–3). The overall diagnostic yield of MOSE was of 90 % (confidence interval [CI] 86 %–92 %). On multivariable logistic regression analysis, variables independently associated with the diagnostic yield of MOSE were a larger needle diameter (20G vs. 25G, OR 11.64, 95 %CI 3.5–38.71; 22G vs. 25G, OR 6.20, 95 %CI 2.41–15.90) and three of more needle passes (OR 3.39, 95 %CI 1.38–8.31). Conclusions  MOSE showed high diagnostic yield and accuracy. Its yield was further increased if performed with a large size FNB needles and more than two passes. Georg Thieme Verlag KG 2021-06 2021-05-27 /pmc/articles/PMC8159577/ /pubmed/34079874 http://dx.doi.org/10.1055/a-1395-7129 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Mangiavillano, Benedetto
Frazzoni, Leonardo
Togliani, Thomas
Fabbri, Carlo
Tarantino, Ilaria
De Luca, Luca
Staiano, Teresa
Binda, Cecilia
Signoretti, Marianna
Eusebi, Leonardo H.
Auriemma, Francesco
Lamonaca, Laura
Paduano, Danilo
Di Leo, Milena
Carrara, Silvia
Fuccio, Lorenzo
Repici, Alessandro
Macroscopic on-site evaluation (MOSE) of specimens from solid lesions acquired during EUS-FNB: multicenter study and comparison between needle gauges
title Macroscopic on-site evaluation (MOSE) of specimens from solid lesions acquired during EUS-FNB: multicenter study and comparison between needle gauges
title_full Macroscopic on-site evaluation (MOSE) of specimens from solid lesions acquired during EUS-FNB: multicenter study and comparison between needle gauges
title_fullStr Macroscopic on-site evaluation (MOSE) of specimens from solid lesions acquired during EUS-FNB: multicenter study and comparison between needle gauges
title_full_unstemmed Macroscopic on-site evaluation (MOSE) of specimens from solid lesions acquired during EUS-FNB: multicenter study and comparison between needle gauges
title_short Macroscopic on-site evaluation (MOSE) of specimens from solid lesions acquired during EUS-FNB: multicenter study and comparison between needle gauges
title_sort macroscopic on-site evaluation (mose) of specimens from solid lesions acquired during eus-fnb: multicenter study and comparison between needle gauges
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159577/
https://www.ncbi.nlm.nih.gov/pubmed/34079874
http://dx.doi.org/10.1055/a-1395-7129
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