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A case of Helicobacter pylori -negative early gastric adenocarcinoma with gastrointestinal phenotype

A 40-year-old man with slightly depressed (0-IIc) type gastric cancer of the pyloric anterior gastric area underwent pre-operative screening for tetralogy of Fallot and endoscopic submucosal dissection (ESD) and was tested for Helicobacter pylori antigens and antibodies. Both tests were negative. He...

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Autores principales: Takatsuna, Masafumi, Azumi, Rie, Mizusawa, Takeshi, Sato, Hiroki, Mizuno, Ken-Ichi, Kato, Takashi, Yokoyama, Junji, Ajioka, Yoichi, Terai, Shuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159579/
https://www.ncbi.nlm.nih.gov/pubmed/34079868
http://dx.doi.org/10.1055/a-1396-3854
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author Takatsuna, Masafumi
Azumi, Rie
Mizusawa, Takeshi
Sato, Hiroki
Mizuno, Ken-Ichi
Kato, Takashi
Yokoyama, Junji
Ajioka, Yoichi
Terai, Shuji
author_facet Takatsuna, Masafumi
Azumi, Rie
Mizusawa, Takeshi
Sato, Hiroki
Mizuno, Ken-Ichi
Kato, Takashi
Yokoyama, Junji
Ajioka, Yoichi
Terai, Shuji
author_sort Takatsuna, Masafumi
collection PubMed
description A 40-year-old man with slightly depressed (0-IIc) type gastric cancer of the pyloric anterior gastric area underwent pre-operative screening for tetralogy of Fallot and endoscopic submucosal dissection (ESD) and was tested for Helicobacter pylori antigens and antibodies. Both tests were negative. He did not have a history of eradication. Pathological diagnosis of ESD showed a well-differentiated adenocarcinoma. The tumor was CD10-positive, MUC5AC-negative, and MUC6-confocal positive; it showed differentiation with gastrointestinal phenotype. Moreover, the tumor cells were lysozyme-positive, resembling Paneth cells. Mucosal glands exhibited intestinal metaplasia on the anal side of the tumor lesion. On the oral side of the tumor, metaplasia was non-existent, with normal pyloric glands present in the mucosal layer. The patient was not infected with H. pylori ; however, intestinal metaplasia existed around the early gastric cancer. This suggested that the intestinal metaplasia occurred due to bile reflux, and the gastric neoplasia arose with the metaplasia without an H. pylori infection. This case may potentially help explain gastric cancer development in the absence of H. pylori infection.
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spelling pubmed-81595792021-06-01 A case of Helicobacter pylori -negative early gastric adenocarcinoma with gastrointestinal phenotype Takatsuna, Masafumi Azumi, Rie Mizusawa, Takeshi Sato, Hiroki Mizuno, Ken-Ichi Kato, Takashi Yokoyama, Junji Ajioka, Yoichi Terai, Shuji Endosc Int Open A 40-year-old man with slightly depressed (0-IIc) type gastric cancer of the pyloric anterior gastric area underwent pre-operative screening for tetralogy of Fallot and endoscopic submucosal dissection (ESD) and was tested for Helicobacter pylori antigens and antibodies. Both tests were negative. He did not have a history of eradication. Pathological diagnosis of ESD showed a well-differentiated adenocarcinoma. The tumor was CD10-positive, MUC5AC-negative, and MUC6-confocal positive; it showed differentiation with gastrointestinal phenotype. Moreover, the tumor cells were lysozyme-positive, resembling Paneth cells. Mucosal glands exhibited intestinal metaplasia on the anal side of the tumor lesion. On the oral side of the tumor, metaplasia was non-existent, with normal pyloric glands present in the mucosal layer. The patient was not infected with H. pylori ; however, intestinal metaplasia existed around the early gastric cancer. This suggested that the intestinal metaplasia occurred due to bile reflux, and the gastric neoplasia arose with the metaplasia without an H. pylori infection. This case may potentially help explain gastric cancer development in the absence of H. pylori infection. Georg Thieme Verlag KG 2021-06 2021-05-27 /pmc/articles/PMC8159579/ /pubmed/34079868 http://dx.doi.org/10.1055/a-1396-3854 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Takatsuna, Masafumi
Azumi, Rie
Mizusawa, Takeshi
Sato, Hiroki
Mizuno, Ken-Ichi
Kato, Takashi
Yokoyama, Junji
Ajioka, Yoichi
Terai, Shuji
A case of Helicobacter pylori -negative early gastric adenocarcinoma with gastrointestinal phenotype
title A case of Helicobacter pylori -negative early gastric adenocarcinoma with gastrointestinal phenotype
title_full A case of Helicobacter pylori -negative early gastric adenocarcinoma with gastrointestinal phenotype
title_fullStr A case of Helicobacter pylori -negative early gastric adenocarcinoma with gastrointestinal phenotype
title_full_unstemmed A case of Helicobacter pylori -negative early gastric adenocarcinoma with gastrointestinal phenotype
title_short A case of Helicobacter pylori -negative early gastric adenocarcinoma with gastrointestinal phenotype
title_sort case of helicobacter pylori -negative early gastric adenocarcinoma with gastrointestinal phenotype
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159579/
https://www.ncbi.nlm.nih.gov/pubmed/34079868
http://dx.doi.org/10.1055/a-1396-3854
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