Development of a gel dedicated to gel immersion endoscopy

Backgrounds and study aims  Gel immersion endoscopy is a novel technique to secure the visual field during endoscopy. The aim of this study was to develop a dedicated gel for this technique. Methods  To identify appropriate viscoelasticity and electrical conductivity, various gels were examined. Bas...

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Autores principales: Yano, Tomonori, Ohata, Atsushi, Hiraki, Yuji, Tanaka, Makoto, Shinozaki, Satoshi, Lefor, Alan Kawarai, Yamamoto, Hironori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159604/
https://www.ncbi.nlm.nih.gov/pubmed/34079878
http://dx.doi.org/10.1055/a-1396-4236
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author Yano, Tomonori
Ohata, Atsushi
Hiraki, Yuji
Tanaka, Makoto
Shinozaki, Satoshi
Lefor, Alan Kawarai
Yamamoto, Hironori
author_facet Yano, Tomonori
Ohata, Atsushi
Hiraki, Yuji
Tanaka, Makoto
Shinozaki, Satoshi
Lefor, Alan Kawarai
Yamamoto, Hironori
author_sort Yano, Tomonori
collection PubMed
description Backgrounds and study aims  Gel immersion endoscopy is a novel technique to secure the visual field during endoscopy. The aim of this study was to develop a dedicated gel for this technique. Methods  To identify appropriate viscoelasticity and electrical conductivity, various gels were examined. Based on these results, the dedicated gel “OPF-203” was developed. Efficacy and safety of OPF-203 were evaluated in a porcine model. Results  In vitro experiments showed that a viscosity of 230 to 1900 mPa·s, loss tangent (tanδ) ≤ 0.6, and hardness of 240 to 540 N/cm (2) were suitable. Ex vivo experiments showed electrical conductivity ≤ 220 μS/cm is appropriate. In vivo experiments using gastrointestinal bleeding showed that OPF-203 provided clear visualization compared to water. After electrocoagulation of gastric mucosa in OPF-203, severe coagulative necrosis was not observed in the muscularis but limited to the mucosa. Conclusions  OPF-203 is useful for gel immersion endoscopy.
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spelling pubmed-81596042021-06-01 Development of a gel dedicated to gel immersion endoscopy Yano, Tomonori Ohata, Atsushi Hiraki, Yuji Tanaka, Makoto Shinozaki, Satoshi Lefor, Alan Kawarai Yamamoto, Hironori Endosc Int Open Backgrounds and study aims  Gel immersion endoscopy is a novel technique to secure the visual field during endoscopy. The aim of this study was to develop a dedicated gel for this technique. Methods  To identify appropriate viscoelasticity and electrical conductivity, various gels were examined. Based on these results, the dedicated gel “OPF-203” was developed. Efficacy and safety of OPF-203 were evaluated in a porcine model. Results  In vitro experiments showed that a viscosity of 230 to 1900 mPa·s, loss tangent (tanδ) ≤ 0.6, and hardness of 240 to 540 N/cm (2) were suitable. Ex vivo experiments showed electrical conductivity ≤ 220 μS/cm is appropriate. In vivo experiments using gastrointestinal bleeding showed that OPF-203 provided clear visualization compared to water. After electrocoagulation of gastric mucosa in OPF-203, severe coagulative necrosis was not observed in the muscularis but limited to the mucosa. Conclusions  OPF-203 is useful for gel immersion endoscopy. Georg Thieme Verlag KG 2021-06 2021-05-27 /pmc/articles/PMC8159604/ /pubmed/34079878 http://dx.doi.org/10.1055/a-1396-4236 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Yano, Tomonori
Ohata, Atsushi
Hiraki, Yuji
Tanaka, Makoto
Shinozaki, Satoshi
Lefor, Alan Kawarai
Yamamoto, Hironori
Development of a gel dedicated to gel immersion endoscopy
title Development of a gel dedicated to gel immersion endoscopy
title_full Development of a gel dedicated to gel immersion endoscopy
title_fullStr Development of a gel dedicated to gel immersion endoscopy
title_full_unstemmed Development of a gel dedicated to gel immersion endoscopy
title_short Development of a gel dedicated to gel immersion endoscopy
title_sort development of a gel dedicated to gel immersion endoscopy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159604/
https://www.ncbi.nlm.nih.gov/pubmed/34079878
http://dx.doi.org/10.1055/a-1396-4236
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