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Cytoplasmic-predominant Pten increases microglial activation and synaptic pruning in a murine model with autism-like phenotype
Germline mutations in PTEN account for ~10% of cases of autism spectrum disorder (ASD) with coincident macrocephaly. To explore the importance of nuclear PTEN in the development of ASD and macrocephaly, we previously generated a mouse model with predominantly cytoplasmic localization of Pten (Pten(m...
Autores principales: | Sarn, Nicholas, Jaini, Ritika, Thacker, Stetson, Lee, Hyunpil, Dutta, Ranjan, Eng, Charis |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159731/ https://www.ncbi.nlm.nih.gov/pubmed/32055008 http://dx.doi.org/10.1038/s41380-020-0681-0 |
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