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The prevalence and clinical relevance of 2R/2R TYMS genotype in patients with gastrointestinal malignancies treated with fluoropyrimidine-based chemotherapy regimens
INTRODUCTION: The prevalence of 2R/2R TYMS genotype is variable but estimated to be around 20–30% in Caucasians. The clinical relevance of TYMS 2R/2R genotype in predicting severe fluoropyrimidine-related adverse events (FrAE) is controversial. Here, we explored the prevalence and clinical relevance...
Autores principales: | Khushman, Moh’d, Patel, Girijesh Kumar, Maharjan, Anu Singh, McMillin, Gwendolyn A., Nelson, Cindy, Hosein, Peter, Singh, Ajay P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159739/ https://www.ncbi.nlm.nih.gov/pubmed/33608662 http://dx.doi.org/10.1038/s41397-021-00210-2 |
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